4569-34-0

Basic information

• Product Name: Phosphine oxide, (1-methylethenyl)diphenyl-
• CAS NO: 4569-34-0
• Molecular Formula: C15H15OP
• Molecular Weight: 242.257
• Mol File: 4569-34-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Phosphine oxide, (1-methylethenyl)diphenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphine oxide, (1-methylethenyl)diphenyl-(4569-34-0)
• EPA Substance Registry System: Phosphine oxide, (1-methylethenyl)diphenyl-(4569-34-0)

Safety Data

• Hazardous Substances Data: 4569-34-0(Hazardous Substances Data)

Upstream product

• 557-93-7 2-bromoprop-1-ene 
• 4559-70-0 Diphenylphosphine oxide 
• 1079-66-9 chloro-diphenylphosphine 
• 80340-39-2 5-methoxy-4-methyl-5,5-diphenyl-Δ²-1,2,5λ⁵-oxazaphospholine 2-oxide 
• 74-88-4 methyl iodide 
• 719-80-2 Ethyl diphenylphosphinite 
• 3156-70-5 1-Nitropropen 
• 4020-99-9 diphenylphosphinous acid methyl ester 
• 97531-39-0 (1-Methyl-1,2-epoxyethyl)-diphenylphosphine oxide 
• 16433-97-9 (2-propen-2-yl)diphenylphosphane 

Downstream Products

• 136835-06-8 (3R,4R)-1-(2-Diphenylphosphanyl-propyl)-3,4-dimethoxy-phospholane 
• 136835-05-7 (3aR,6aR)-5-[2-(Diphenyl-phosphinoyl)-propyl]-2,2-dimethyl-tetrahydro-phospholo[3,4-d][1,3]dioxole 
• 136835-04-6 (3R,4R)-1-[2-(Diphenyl-phosphinoyl)-propyl]-3,4-dimethoxy-phospholane 

Relevant articles and documents

Copper-Catalyzed C?P Cross-Coupling of (Cyclo)alkenyl/Aryl Bromides and Secondary Phosphine Oxides with in situ Halogen Exchange

An efficient protocol for concurrent tandem halogen exchange/C?P cross-coupling of cycloalkenyl bromides and secondary phosphine oxides has been developed. The catalytic system is based on cheap and air-stable copper(I) iodide as the precatalyst, commercially available N,N’-dimethylethylenediamine as the ligand, and Cs2CO3 or K2CO3 as the base. The use of sodium iodide as an additive reduces the excessive use of organic bromides to near-stoichiometric by promoting the in situ transformation to the corresponding iodides. Diarylphosphine oxides undergo cycloalkenylation with 35–99 % yields and dicyclohexylphosphine oxide with 30–53 % yields. In the case of acyclic alkenyl bromides the cross-coupling products undergo conjugate addition of diphenylphosphine oxide and satisfying yields are observed only for internal olefins. In the case of aryl bromides satisfying yields (43–72 %) are observed only for sterically unhindered arenes or arenes possessing an ortho-directing group. Cycloalkenylphosphine oxides prepared in the cross-coupling reaction undergo base-catalyzed and base-promoted conjugate addition to give bis(phosphinoyl)cycloalkanes.

Novel Preparation of Diphenylvinylphosphine Oxides via Direct Deoxygenation of 1,2-Epoxyethyldiphenylphosphine Oxides with Diphosphorus Tetraiodide

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ENEPHOSPHINILATION

A general method is described for the formation of vinylphosphines from arylsulfonylhydrazones.Oxidation of the resulting vinylphosphines yields phosphine oxides.