45744-18-1

Basic information

• Product Name: SALICYLALDEHYDE HYDRAZONE
• Synonyms: Benzenecarboximidamide, 2-hydroxy- (9CI)
• CAS NO: 45744-18-1
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15122
• Product Categories: AMIDINE
• Mol File: 45744-18-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 97.5°C
• Boiling Point: 250.42°C (rough estimate)
• Appearance: /
• Density: 1.1778 (rough estimate)
• Refractive Index: 1.5660 (estimate)
• CAS DataBase Reference: SALICYLALDEHYDE HYDRAZONE(CAS DataBase Reference)
• NIST Chemistry Reference: SALICYLALDEHYDE HYDRAZONE(45744-18-1)
• EPA Substance Registry System: SALICYLALDEHYDE HYDRAZONE(45744-18-1)

Safety Data

• Hazardous Substances Data: 45744-18-1(Hazardous Substances Data)

Upstream product

• 6005-58-9 N',2-dihydroxybenzimidamide 
• 90-02-8 salicylaldehyde 
• 74511-44-7 o-(benzyloxy)benzonitrile 
• 611-20-1 salicylonitrile 
• 177995-39-0 6-bromo-3-amino-1,2-benzisoxazole 
• 36216-80-5 3-amino-1,2-benzisoxazole 
• 96932-65-9 4-[(2-hydroxy-phenyl)-methylsulfanyl-methylene]-morpholinium; iodide 
• 51618-01-0 ethyl 2-hydroxybenzimidate hydrochloride 

Downstream Products

• 501904-25-2 2-hydroxybenzene-1-carboximidamide hydrochloride 
• 76467-22-6 2-(2-hydroxyphenyl)-6-methyl-4(3H)-pyrimidinone 

Relevant articles and documents

The Preparation Method of UV absorber intermediates

The present invention relates to a method for preparing 2-hydroxybenzamidine. According to the present invention, 2-hydroxybenzonitrile is reacted with NH_2OH to prepare a 2-hydroxybenzamide oxime, and 2-hydroxybenzamide oxime is reacted with ammonium chl

Preparation of cyclic boramides from salicylaldehydes, ammonium acetate and sodium borohydride

Borohydride reduction of salicylaldehyde imines yields surprisingly a cyclic boramide. This is a fairly stable compound, and X-ray analysis shows it has a tetrahedral boron atom. Mechanistic studies show a reaction pathway through an oxazaborinane intermediate. The reaction also works with halogen substituted salicylaldehydes and for the preparation of non-symmetrical boramides.

Preparation of 2-hydroxybenzamidines from 3-aminobenzisoxazoles

2-Hydroxybenzamidines have been prepared from 3-aminobenzisoxazoles by reductive cleavage of the nitrogen-oxygen bond using catalytic hydrogenation, Zn/AcOH or NiCl2/NaBH4. This ring-opening reaction can be accomplished chemoselectively in the presence of a variety of hydrogenation-sensitive functional groups including an aryl bromide, benzyl carbamate, and olefin.