457655-68-4Relevant articles and documents
SYNTHESIS OF ISOFLAVANES AND INTERMEDIATES THEREOF
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Page/Page column 25, (2016/04/20)
Subject of the invention is a method for enantioselective production of an isoflavane from an isoflavone, comprising the steps: (a) selectively reducing the isoflavone, such that the 4-keto group of the isoflavone is converted to a 4-hydroxy group, and the 2,3-double bond of the isoflavone is converted to a 2,3-single bond, thereby obtaining a 4-hydroxy intermediate, and (b) reacting the 4-hydroxy intermediate with a chiral reagent, such that a chiral group is covalently attached to the C4-position of the 4-hydroxy intermediate, thereby obtaining a chiral intermediate. The invention also relates to intermediates of formulae (IV), (V), (VI) and (VII) obtainable in the inventive process.
A Synthesis of Hydroxylated Isoflavylium Salts and Their Reduction Products
Liepa, Andris J.
, p. 2647 - 2655 (2007/10/02)
Phloroglucinol reacts with arylmalondialdehydes in the presence of hydrochloric acid to form 5,7-dihydroxyisoflavylium salts.Reduction of these salts can be utilized to form isoflav-2-enes, isoflav-3-enes or isoflavans.