458529-69-6

Basic information

• Product Name: Carbamic acid, [(1S)-3-(methoxymethylamino)-3-oxo-1-phenylpropyl]-, 1,1-dimethylethyl ester
• CAS NO: 458529-69-6
• Molecular Formula: C16H24N2O4
• Molecular Weight: 308.378
• Mol File: 458529-69-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1S)-3-(methoxymethylamino)-3-oxo-1-phenylpropyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-3-(methoxymethylamino)-3-oxo-1-phenylpropyl]-, 1,1-dimethylethyl ester(458529-69-6)
• EPA Substance Registry System: Carbamic acid, [(1S)-3-(methoxymethylamino)-3-oxo-1-phenylpropyl]-, 1,1-dimethylethyl ester(458529-69-6)

Safety Data

• Hazardous Substances Data: 458529-69-6(Hazardous Substances Data)

Upstream product

• 3082-69-7 ethyl (3S)-3-amino-3-phenylpropionate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 6638-79-5 N,O-dimethylhydroxylamine*hydrochloride 
• 167834-23-3 ethyl (3S)-3-{[(tert-butoxy)carbonyl]amino}-3-phenylpropanoate 

Downstream Products

• 667402-23-5 (S)-[3-(4-{ethyl-[2-(4-methanesulfonylphenyl)-acetyl]-amino}-piperidin-1-yl)-1-phenyl-propyl]-carbamic acid 1',1',1'-trichloroethoxy ester hydrochloride 
• 667402-02-0 (S)-1-benzenesulfonyl-piperidine-4-carboxylic acid [3-(4-{ethyl-[2-(4-methanesulfonyl-phenyl)-acetyl]-amino}-piperidin-1-yl)-1-phenyl-propyl]-amide 
• 872001-88-2 C₁₆H₂₃NO₄ 
• 528586-23-4 tert-butyl ((1S)-3-oxo-1-phenylbutyl)carbamate 
• 135865-78-0 tert-butyl (1S)-3-oxo-1-phenylpropylcarbamate 

Relevant articles and documents

1-Amido-1-phenyl-3-piperidinylbutanes - CCR5 antagonists for the treatment of HIV: Part 2

Optimisation of a series of 4-piperidinyltriazoles led to the identification of compound 28a which showed good whole cell antiviral activity, excellent selectivity over the hERG ion channel and complete oral absorption.

TRIAZOLYLPIPERIDINE DERIVATIVES AND USE THEREOF IN THERAPY

The present invention provides compounds of formula (I) Wherein R1 , R2, R3 , R4 , Het and m are as defined in the description. The compounds of the present invention are modulators, especially antagonists, of the activity of chemokine CCR5 receptors.