458532-96-2 Usage
Description
2-Chloro-4-pyridylboronic acid is a white solid chemical compound that serves as a versatile reagent and substrate in various chemical reactions and pharmaceutical applications. It is characterized by its chemical properties, which include the presence of a chlorine atom at the 2nd position and a boronic acid group at the 4th position of the pyridine ring. This unique structure allows it to participate in a range of reactions, making it a valuable compound in the fields of organic chemistry and medicinal chemistry.
Uses
Used in Organic Chemistry:
2-Chloro-4-pyridylboronic acid is used as a substrate in peroxide-mediated hydroxydeboronation reactions, which provide good yields of halohydroxypyridines. These halohydroxypyridines are important intermediates in the synthesis of various pharmaceutical compounds and have potential applications in the development of new drugs.
Used in Pharmaceutical Industry:
2-Chloro-4-pyridylboronic acid is used as a reagent for the preparation of IRAK-4 inhibitors. IRAK-4 (interleukin-1 receptor-associated kinase 4) is a key enzyme involved in the regulation of inflammatory responses and plays a crucial role in the activation of the immune system. Inhibitors of IRAK-4 have potential therapeutic applications in the treatment of various inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, and asthma.
Check Digit Verification of cas no
The CAS Registry Mumber 458532-96-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,5,8,5,3 and 2 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 458532-96:
(8*4)+(7*5)+(6*8)+(5*5)+(4*3)+(3*2)+(2*9)+(1*6)=182
182 % 10 = 2
So 458532-96-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H5BClNO2/c7-5-3-4(6(9)10)1-2-8-5/h1-3,9-10H
458532-96-2Relevant articles and documents
Flow Chemistry on Multigram Scale: Continuous Synthesis of Boronic Acids within 1 s
Hafner, Andreas,Meisenbach, Mark,Sedelmeier, Joerg
supporting information, p. 3630 - 3633 (2016/08/16)
The benefits and limitations of a simple continuous flow setup for handling and performing of organolithium chemistry on the multigram scale is described. The developed metalation platform embodies a valuable complement to existing methodologies, as it combines the benefits of Flash Chemistry (chemical synthesis on a time scale of 1 s) with remarkable throughput (g/min) while mitigating the risk of blockages.
