459-98-3

Basic information

• Product Name: N-(2-chloroethyl)-2-fluoroacetamide
• Synonyms: acetamide, N-(2-chloroethyl)-2-fluoro-; N-(2-Chloroethyl)-2-fluoroacetamide
• CAS NO: 459-98-3
• Molecular Formula: C₄H₇ClFNO
• Molecular Weight: 139.5559
• Mol File: 459-98-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 295.8°C at 760 mmHg
• Flash Point: 132.7°C
• Density: 1.189g/cm³
• Vapor Pressure: 0.00149mmHg at 25°C
• Refractive Index: 1.412
• CAS DataBase Reference: N-(2-chloroethyl)-2-fluoroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-chloroethyl)-2-fluoroacetamide(459-98-3)
• EPA Substance Registry System: N-(2-chloroethyl)-2-fluoroacetamide(459-98-3)

Safety Data

• Hazardous Substances Data: 459-98-3(Hazardous Substances Data)

Upstream product

• 359-06-8 monofluoroacetyl chloride 
• 141-43-5 ethanolamine 
• 371-38-0 N-(2-hydroxyethyl)fluoroacetamide 

Relevant articles and documents

Synthesis of 2-[(2-chloro-2′-[18F]fluoroethyl)amino]-2H-1, 3,2-oxazaphosphorinane-2-oxide (18F-fluorocyclophosphamide), a potential tracer for breast tumor prognostic imaging with PET

A fluorine-18 labeled analog of the widely used chemotherapeutic agent cyclophosphamide was synthesized as a tracer for prognostic imaging with positron emission tomography. 2-[(2-Chloro-2′-[18F]fluoroethyl) amino]-2H-1,3,2-oxazaphosphorinane-2-oxide (18F- fluorocyclophosphamide), was prepared by direct halogen exchange reaction from the parent cyclophosphamide. In small-scale syntheses, radiochemical yields of up to 4.9% and specific activities of 960 Ci/mmol were achieved in a total synthesis time of 60-75 min. The [18F]-labeled cyclophosphamide analog with radioactive purity >99% and chemical purity >96% was suitable for in vivo (microPET imaging) and ex vivo studies of a murine model of human breast tumors. Copyright