459434-40-3

Basic information

• Product Name: 3-AMINO-N-METHYLBENZENESULFONAMIDE
• Synonyms: N-METHYL 3-AMINOBENZENESULFONAMIDE;3-AMINO-N-METHYLBENZENESULFONAMIDE;3-amino-N-methylbenzenesulfonamide(SALTDATA: HCl)
• CAS NO: 459434-40-3
• Molecular Formula: C7H10N2O2S
• Molecular Weight: 186.23
• Product Categories: Amines;blocks;Sulfonamides
• Mol File: 459434-40-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 375.7 °C at 760 mmHg
• Flash Point: 181 °C
• Appearance: /
• Density: 1.308 g/cm³
• Vapor Pressure: 7.64E-06mmHg at 25°C
• Refractive Index: 1.581
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 11.66±0.30(Predicted)
• CAS DataBase Reference: 3-AMINO-N-METHYLBENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-N-METHYLBENZENESULFONAMIDE(459434-40-3)
• EPA Substance Registry System: 3-AMINO-N-METHYLBENZENESULFONAMIDE(459434-40-3)

Safety Data

• Hazardous Substances Data: 459434-40-3(Hazardous Substances Data)

Usage

General Description

3-Amino-N-methylbenzenesulfonamide is a chemical compound that is a derivative of sulfonamide and is often utilized in the manufacturing of specific types of pharmaceuticals due to its antibiotic properties. However, it requires careful handling due to its potential toxicity and irritation to the eyes and skin. Its molecular formula is C7H10N2O2S and has a molar mass of 186.23 g/mol. In its structure, a sulfonamide group is bonded to a methylated aniline group. Its applications extend to various industries apart from pharmaceuticals, including agriculture, dye, and others.

InChI:InChI=1/C7H10N2O2S/c1-9-12(10,11)7-4-2-3-6(8)5-7/h2-5,9H,8H2,1H3

Upstream product

• 89599-01-9 3-bromobenzenesulfonamide 
• 153435-79-1 N-methyl-3-bromobenzenesulfonamide 
• 121-51-7 3-nitrobenzenesulphonyl chloride 
• 58955-78-5 N-methyl-3-nitrobenzenesulfonamide 

Downstream Products

• 1028253-56-6 3-methyl-N-(3-(methylsulfamoyl)phenyl)-D-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide 
• 1028253-55-5 3-methyl-N-(3-(methylsulfamoyl)phenyl)-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N-((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide 
• 1315512-70-9 3-({4-[(4-chlorophenyl)amino]-1,3,5-triazin-2-yl}amino)-N-methylbenzenesulfonamide 
• 1315512-69-6 N-methyl-3-({4-[(3-methylphenyl)amino]-1,3,5-triazin-2-yl}amino)benzenesulfonamide 
• 1351089-89-8 N-methyl-3-[(5-methyl-1H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]benzenesulfonamide 
• 1300026-86-1 4-({3-[(methylamino)sulfonyl]phenyl}amino)-9H-pyrimido[4,5-b]indol-7-carboxylic acid 
• 1315512-77-6 3-{[4-({3-[(methylamino)sulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}benzamide trifluoroacetate 
• 1315512-76-5 3-{[4-({3-[(methylamino)sulfonyl]phenyl}amino)-1,3,5-triazin-2-yl]amino}benzamide 
• 57946-88-0 N-Methyl-3-trifluoromethanesulfonylamino-benzenesulfonamide 

Relevant articles and documents

N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)]

A ruthenium complex [(p-cymene)Ru(2,2′-bpyO)(H2O)] was found to be a general and efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate salt. Moreover, a series of sensitive substituents, such as nitro, ester, cyano, and vinyl groups, were tolerated under present conditions. It was confirmed that OH units in the ligand are crucial for the catalytic activity. Notably, this research exhibited the potential of metal-ligand bifunctional ruthenium catalysts for the hydrogen autotransfer process.

SUBSTITUTED AMIDE COMPOUNDS USEFUL AS FARNESOID X RECEPTOR MODULATORS

Disclosed are compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or solvate thereof, wherein Q is: (i) halo, cyano, hydroxyl, NRxRx, C(O)OH, C(O)NH2, C1-6 alkyl substituted with zero to 6 R1a, or P(O)R1cR1c; or (ii) L R1; and A, X1, X2, X3, X4, Z1, Z2, R1, R1a, R1c, R2, R3a, R3b, Rx, L, a, b, and d are defined herein. Also disclosed are methods of using these compounds to modulate the activity of farnesoid X receptor (FXR); pharmaceutical compositions comprising these compounds; and methods of treating a disease, disorder, or condition associated with FXR dysregulation, such as pathological fibrosis, transplant rejection, cancer, osteoporosis, and inflammatory disorders, by using the compounds and pharmaceutical compositions.

Synthesis and biological evaluation of novel 3-(quinolin-4-ylamino)benzenesulfonamidesAQ3 as carbonic anhydrase isoforms I and II inhibitors

Carbonic anhydrases (CAs, EC 4.2.1.1) are crucial metalloenzymes that are involved in diverse bioprocesses. We report the synthesis and biological evaluation of novel series of benzenesulfonamides incorporating un/substituted ethyl quinoline-3-carboxylate moieties. The newly synthesised compounds were in vitro evaluated as inhibitors of the cytosolic human (h) isoforms hCA I and II. Both isoforms hCA I and II were inhibited by the quinolines reported here in variable degrees: hCA I was inhibited with KIs in the range of 0.966–9.091 μM, whereas hCA II in the range of 0.083–3.594 μM. The primary 7-chloro-6-flouro substituted sulphfonamide derivative 6e (KI = 0.083 μM) proved to be the most active quinoline in inhibiting hCA II, whereas, its secondary sulfonamide analog failed to inhibit the hCA II up to 10 μM, confirming the crucial role of the primary sulphfonamide group, as a zinc-binding group for CA inhibitory activity.