45965-30-8

Basic information

• Product Name: 2-Acetamido-5-chloropyridine
• Synonyms: 2-Acetamido-5-chloropyridine;N-(5-chloro-2-pyridinyl)acetamide;Acetamide,N-(5-chloro-2-pyridinyl)-
• CAS NO: 45965-30-8
• Molecular Formula: C₇H₇ClN₂O
• Molecular Weight: 170.59628
• Mol File: 45965-30-8.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Acetamido-5-chloropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Acetamido-5-chloropyridine(45965-30-8)
• EPA Substance Registry System: 2-Acetamido-5-chloropyridine(45965-30-8)

Safety Data

• Hazardous Substances Data: 45965-30-8(Hazardous Substances Data)

Usage

General Description

2-Acetamido-5-chloropyridine is a chemical compound with the molecular formula C7H7ClN2O. It is a derivative of pyridine, with a chlorine atom located at the 5-position and an acetamido group at the 2-position. 2-Acetamido-5-chloropyridine is often used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has also been studied for its potential as a building block for the preparation of heterocyclic compounds with biological activity. 2-Acetamido-5-chloropyridine is a valuable tool for medicinal chemistry research and has potential applications in drug discovery and development. It is important to handle this chemical with care and follow all appropriate safety protocols when working with it in a laboratory setting.

Upstream product

• 5231-96-9 N-(2-pyridyl)acetamide 
• 1480-65-5 2-fluoro-5-chloropyridine 
• 124-42-5 acetamidine hydrochloride 
• 1072-98-6 5-chloro-2-pyridylamine 
• 75-05-8 acetonitrile 
• 127-19-5 N,N-dimethyl acetamide 
• 1197040-29-1 phenyl isocyanate 
• 107264-04-0 N-Fluoro-3-chloropyridinium triflate 
• 108-24-7 acetic anhydride 

Relevant articles and documents

Access to 2-pyridinylamide and imidazopyridine from 2-fluoropyridine and amidine hydrochloride

Under catalyst-free conditions, an efficient method to synthesize 2-pyridinylamides has been developed, and the protocol uses inexpensive and readily available 2-fluoropyridine and amidine derivatives as the starting materials. Simultaneously, the copper-catalysed approach to imidazopyridine derivatives has been established with high chemoselectivity and regiospecificity. The results suggest that the nitrogen-heterocycles containing iodide substituents can also be compatible for the reaction via the cascade Ullmann-type coupling, and the nucleophilic substitution reaction provides the target products in a one-pot manner.

Synthetic method of 2-acetamido-5-chloropyridine

The invention relates to a synthetic method of 2-acetamido-5-chloropyridine. The synthetic method comprises the following steps: making 2-amino-5-chloropyridine and acetic anhydride which are taken as raw materials continuously react in a mass ratio of 1 to (1.0-3.2) in a proper solvent at the temperature of 50 to 110 DEG C for 4 to 15 hours to generate a 2-amino-5-chloropyridine rough product; purifying to obtain a 2-amino-5-chloropyridine pure product. In the synthetic method, the raw materials are readily-available, and are reasonable in costs; meanwhile, in the preparation process, heavy metal and corrosive gas are not used, the reaction is mild, special requirements on reaction equipment are avoided, and ordinary corrosion-resistant equipment can be used for producing; moreover, the synthetic method is moderate in reaction conditions, and does not cause no any environmental pollution.

Convenient N-acetylation of amines in N,N-dimethylacetamide with N,N-carbonyldiimidazole

Dimethylacetamide (DMAc) acts as an efficient source of acetyl and dimethylamine gas in the presence of N,N-carbonyldiimidazole (CDI). Addition of amines to the reaction mixture delivers the corresponding amides in good to excellent yields. The acetylation of amines reported herein, which relies on the in situ generation of N-acetylimidazole on warming of DMAc with CDI at 120-125 °C, serves as a convenient alternative to other acetylation methods.