459860-95-8

Basic information

• Product Name: 2-(4-fluorophenyl)-5-(ethylthio)-1,3,4-oxadiazole
• Synonyms: 2-(4-fluorophenyl)-5-(ethylthio)-1,3,4-oxadiazole
• CAS NO: 459860-95-8
• Molecular Weight: 224.259
• Mol File: 459860-95-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(4-fluorophenyl)-5-(ethylthio)-1,3,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-fluorophenyl)-5-(ethylthio)-1,3,4-oxadiazole(459860-95-8)
• EPA Substance Registry System: 2-(4-fluorophenyl)-5-(ethylthio)-1,3,4-oxadiazole(459860-95-8)

Safety Data

• Hazardous Substances Data: 459860-95-8(Hazardous Substances Data)

Upstream product

• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 74-96-4 ethyl bromide 
• 41421-13-0 2-mercapto-5-(4-fluorophenyl)-1,3,4-oxadiazole 
• 403-33-8 methyl 4-flurobenzoate 
• 456-06-4 4-fluorobenzoyl hydrazide 
• 64-67-5 diethyl sulfate 

Downstream Products

• 1356585-75-5 2-(ethylsulfonyl)-5-(4-fluorophenyl)-1,3,4-oxadiazole 

Relevant articles and documents

1,2,4-TRIAZOLE, 1,3,4-OXADIAZOLE, AND 1,3,4-THIADIAZOLE DERIVATIVES AND THEIR ANTIMYCOBACTERIAL ACTIVITY

Disclosed herein are novel five membered heterocyclic compounds of Formula (I) wherein, X is S or SO2; n is 0, 1; m is1 or 2; Y is N, O or S; R2 independently represents H or alkyl or halo selected from -CI, -F; or -CF3, or -OH or-NH2 or - NO2; and R1 independently represents H or C1 to C5 straight or branched chain alkyl, alkenyl, alkynyl or a group -(CH2)5Br or pyrrolidine or - NHR' wherein R' is H or isopropyl or (II) or (III) which selectively act against dormant pathogenic tuberculi bacilli and exhibit antiproliferative activities and for treatment of a disease or disorder associated with GroEL1/GroEL2 activity. The invention relates to a process for preparation of novel five membered heterocyclic compounds of Formula I and to pharmaceutical compositions thereof.