460081-20-3 Usage
Description
Ethyl 2-bromo-1,3-oxazole-4-carboxylate is an organic compound that serves as a valuable building block in the synthesis of various pharmaceutical and biologically active compounds. Its unique structure, featuring a bromo substituent and an oxazole ring, makes it a versatile intermediate for the development of novel therapeutic agents.
Uses
Used in Pharmaceutical Industry:
Ethyl 2-bromo-1,3-oxazole-4-carboxylate is used as a key intermediate for the synthesis of a wide range of pharmaceutical compounds. Its ability to form stable and bioactive molecules makes it an essential component in the development of new drugs with improved efficacy and safety profiles.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Ethyl 2-bromo-1,3-oxazole-4-carboxylate is used as a versatile building block for the synthesis of C(2)-C(4'') linked poly-oxazoles. These poly-oxazoles have demonstrated potential as therapeutic agents, with applications in various disease areas, including oncology, infectious diseases, and neurological disorders.
Used in Drug Discovery:
Ethyl 2-bromo-1,3-oxazole-4-carboxylate is employed in drug discovery processes to create novel chemical entities with potential therapeutic benefits. Its unique structural features allow for the design of molecules with enhanced binding affinities, selectivity, and pharmacokinetic properties, ultimately leading to the development of more effective treatments for various diseases.
Used in Bioactive Compounds Synthesis:
Ethyl 2-bromo-1,3-oxazole-4-carboxylate is used as a starting material for the synthesis of biologically active compounds, which can exhibit a range of pharmacological effects. These compounds can be further optimized and developed into potential drug candidates, contributing to the advancement of medical treatments and therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 460081-20-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,6,0,0,8 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 460081-20:
(8*4)+(7*6)+(6*0)+(5*0)+(4*8)+(3*1)+(2*2)+(1*0)=113
113 % 10 = 3
So 460081-20-3 is a valid CAS Registry Number.
InChI:InChI=1/C6H6BrNO3/c1-2-10-5(9)4-3-11-6(7)8-4/h3H,2H2,1H3
460081-20-3Relevant articles and documents
Widely Exploited, Yet Unreported: Regiocontrolled Synthesis and the Suzuki–Miyaura Reactions of Bromooxazole Building Blocks
Solomin, Vitalii V.,Radchenko, Dmytro S.,Slobodyanyuk, Evgeniy Y.,Geraschenko, Oleksandr V.,Vashchenko, Bohdan V.,Grygorenko, Oleksandr O.
, p. 2884 - 2898 (2019/03/07)
An approach to synthesis of 2-, 4-, and 5-bromooxazoles is described. The method was optimized, and its scope was extended to all three isomeric parents, as well as various alkyl- and aryl-substituted bromooxazoles. It was found that direct regiocontrolled lithiation followed by reaction with electrophilic bromine source was common for all substrates and led exclusively to the target substituted 2-, 4- and 5-bromooxazoles on multigram scale. The utility of the multipurpose building blocks obtained in this work was demonstrated in the Suzuki–Miyaura cross-coupling reaction under parallel synthesis conditions.
Ethyl 2-chlorooxazole-4-carboxylate: A versatile intermediate for the synthesis of substituted oxazoles
Hodgetts, Kevin J.,Kershaw, Mark T.
, p. 2905 - 2907 (2007/10/03)
(formula presented) R1 = Ar, Het, alkenyl R2 = H, Ar, Het, alkenyl, alkynyl R3 = H, CO2H, Ar, Het, alkenyl, alkynyl By using a sequence of regiocontrolled halogenation and palladium-catalyzed coupling reactions,
