460747-00-6

Basic information

• Product Name: Morpholine, 4-[[6-(4-hydroxy-3-iodophenyl)-3-pyridinyl]carbonyl]-
• CAS NO: 460747-00-6
• Molecular Formula: C16H15IN2O3
• Molecular Weight: 410.211
• Mol File: 460747-00-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Morpholine, 4-[[6-(4-hydroxy-3-iodophenyl)-3-pyridinyl]carbonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-[[6-(4-hydroxy-3-iodophenyl)-3-pyridinyl]carbonyl]-(460747-00-6)
• EPA Substance Registry System: Morpholine, 4-[[6-(4-hydroxy-3-iodophenyl)-3-pyridinyl]carbonyl]-(460747-00-6)

Safety Data

• Hazardous Substances Data: 460747-00-6(Hazardous Substances Data)

Upstream product

• 159191-56-7 (4-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid 
• 67963-68-2 t-butyldimethylsilyl-4-bromophenol 
• 58757-38-3 6-Chloronicotinoyl chloride 
• 64614-49-9 4-[(6-chloro-3-pyridinyl)carbonyl]morpholine 
• 477740-54-8 [6-(4-hydroxy-phenyl)-pyridin-3-yl]-morpholin-4-yl-methanone 

Relevant articles and documents

A new class of potent non-imidazole H3 antagonists: 2-Aminoethylbenzofurans

2-Aminoethylbenzofurans constitute a new class of H3 antagonists that are more rotationally constrained than most previously reported H3 antagonists. They retain high potency at human and rat receptors, with efficient CNS penetration observed in 35. The SAR of the basic amine moiety was compared in three different series of analogues. The greatest potency was found in analogues bearing a 2-methylpyrrolidine, a 2,5-dimethylpyrrolidine, or a 2,6-dimethylpiperidine.

Novel amines as histamine-3 receptor ligands and their therapeutic applications

Compounds of formula (I) or a pharmaceutically acceptable salts or prodrug thereof which are useful for the modulation of the histamine-3 receptors in mammals and which are useful for the treatment of disorders ameliorated by histamine-3 receptor ligands.