460747-73-3

Basic information

• Product Name: (2R)-1-BUT-3-YN-1-YL-2-METHYLPYRROLIDINE
• Synonyms: (2R)-1-BUT-3-YN-1-YL-2-METHYLPYRROLIDINE;1-(3-BUTYNYL)-2(R)-METHYLPYRROLIDINE;Pyrrolidine, 1-(3-butynyl)-2-methyl-, (2R)- (9CI);(R)-1-(but-3-yn-1-yl)-2-methylpyrrolidine
• CAS NO: 460747-73-3
• Molecular Formula: C₉H₁₅N
• Molecular Weight: 137.2221
• Product Categories: AMINETERTIARY
• Mol File: 460747-73-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 185.4±23.0 °C(Predicted)
• Appearance: /
• Density: 0.890±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 9?+-.0.40(Predicted)
• CAS DataBase Reference: (2R)-1-BUT-3-YN-1-YL-2-METHYLPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-1-BUT-3-YN-1-YL-2-METHYLPYRROLIDINE(460747-73-3)
• EPA Substance Registry System: (2R)-1-BUT-3-YN-1-YL-2-METHYLPYRROLIDINE(460747-73-3)

Safety Data

• Hazardous Substances Data: 460747-73-3(Hazardous Substances Data)

Usage

Description

(2R)-1-BUT-3-YN-1-YL-2-METHYLPYRROLIDINE is a pyrrolidine derivative with a butynyl group and a methyl substituent attached to the pyrrolidine ring. It is a chemical compound with a complex molecular structure that may have applications in various fields due to its unique structural features.

Uses

Used in Organic Synthesis:
(2R)-1-BUT-3-YN-1-YL-2-METHYLPYRROLIDINE is used as a building block in organic synthesis for the creation of various complex organic molecules. Its unique structural features and potential reactivity make it a valuable component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
(2R)-1-BUT-3-YN-1-YL-2-METHYLPYRROLIDINE is used as an intermediate in the development of new pharmaceutical compounds. Its unique structure and potential reactivity may contribute to the discovery of novel drug candidates with improved therapeutic properties.
Used in Materials Science:
(2R)-1-BUT-3-YN-1-YL-2-METHYLPYRROLIDINE is used as a component in the development of new materials with specific properties. Its unique structural features may contribute to the creation of advanced materials for various applications, such as sensors, catalysts, or functional coatings.
Further research and analysis are required to fully understand the potential uses and effects of (2R)-1-BUT-3-YN-1-YL-2-METHYLPYRROLIDINE in various applications.

Upstream product

• 23418-85-1 3-butyn-1-yl p-toluenesulfonate 
• 584-08-7 potassium carbonate 
• 41720-98-3 (R)-2-methylpyrrolidine hydrochloride 
• 765-38-8 (R)-(-)-2-methylpyrrolidine 

Downstream Products

• 1610838-96-4 (R)-2-methyl-1-(2-(5-(4-nitrophenoxy)benzofuran-2-yl)ethyl)pyrrolidine 
• 1610838-95-3 (R)-2-methyl-1-(2-(5-(4-fluorophenoxy)benzofuran-2-yl)ethyl)pyrrolidine 
• 1610838-94-2 (R)-2-methyl-1-(2-(5-(2-nitrophenoxy)benzofuran-2-yl)ethyl)pyrrolidine 
• 1610838-90-8 (R)-(3-iodophenyl)(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)methanone 
• 1610838-89-5 (R)-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)(2-nitrophenyl)methanone 
• 1359168-20-9 (R)-(2-(2-(2-methylpyrrolidin-1-yl)ethyl)benzofuran-5-yl)(4-nitrophenyl)methanone 
• 804518-42-1 4-bromo-2-[4-(2-(R)-methyl-pyrrolidin-1-yl)-but-1-ynyl]-phenylamine 
• 460748-56-5 N-methoxy-N-methyl-3-(2-(2-[2(R)-methyl-1-pyrrolidinyl]ethyl)-1-benzofuran-5-yl)benzamide 
• 460748-55-4 3-(2-(2-[2(R)-methyl-1-pyrrolidinyl]ethyl)-1-benzofuran-5-yl)benzoic acid 
• 460748-44-1 1-[3-(2-{2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)phenyl]ethanone 

Relevant articles and documents

Synthesis and biological evaluation of XB-1 analogues as novel histamine H3 receptor antagonists and neuroprotective agents

A novel class of H3 receptor antagonists, XB-1 analogues based on benzophenone or oxydibenzene scaffolds were synthesized, and their biological activities were evaluated to determine their in vitro neuroprotective effects against Aβ25-35-induced damage in primary cortical neurons and against glutamate-induced neuronal injury in primary cerebellar granule neurons. The results indicated that all of the tested analogues displayed neuroprotective activity at 0.1 μM or 1 μM. These findings may provide new insights into the development of novel promising H3 receptor antagonists with potential neuroprotective activity.

Synthesis and SAR of 5-amino- and 5-(aminomethyl)benzofuran histamine H3 receptor antagonists with improved potency

A new series of H3 receptor antagonists was discovered with nanomolar and subnanomolar affinities at human and rat H3 receptors. Starting from an earlier, more structurally limited series of benzofurans, the present series of compounds demonstrated increased structural variety and flexibility with greater in vitro potency. One compound in particular, {2-[2-(2-(R)-methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl}(5-nitropyridin-2-yl) amine (7h), gave the best binding potency (human Ki of 0.05 nM, rat Ki of 0.11 nM), which represented a 9-fold (in human) and an 11-fold (in rat) improvement over ABT-239 (compound 5), a compound previously reported to have excellent in vitro potency and in vivo efficacy. The synthesis, SAR of the H3 binding affinities, in vitro assay for phospholipidosis, and pharmacokinetic properties of the new compounds are described.

Structure-activity relationships of arylbenzofuran H3 receptor antagonists

An SAR study of histamine H3 receptor antagonists based on substituted (R)-2-methyl-1-[2-(5-phenyl-benzofuran-2-yl)-ethyl]-pyrrolidines is presented.