4608-49-5 Usage
Description
Larixyl Acetate, derived from the larch tree (Larix decidua L.), is a bioactive compound with significant pharmacological properties. It has been identified through in vitro anti-inflammatory activity studies conducted on larch sawdust. LARIXYL ACETATE is known for its potential therapeutic applications due to its ability to modulate various biological processes.
Uses
Used in Pharmaceutical Industry:
Larixyl Acetate is used as an anti-inflammatory agent for its demonstrated ability to reduce inflammation in vitro. This property makes it a promising candidate for the development of new drugs targeting inflammatory conditions.
Used in Natural Medicine:
Larixyl Acetate is used as a natural remedy for its potential to alleviate inflammation and promote healing. Its natural origin and demonstrated anti-inflammatory properties make it an attractive option for those seeking alternative, non-synthetic treatments for various health issues.
Used in Cosmetics Industry:
Larixyl Acetate is used as an ingredient in skincare products for its anti-inflammatory and potentially soothing effects on the skin. It may be included in formulations aimed at reducing redness, irritation, and inflammation associated with various skin conditions.
Used in Research and Development:
Larixyl Acetate is used as a subject of study in the field of pharmacology and natural product chemistry. Its anti-inflammatory activity and potential therapeutic applications make it an interesting compound for further research into its mechanisms of action and possible uses in medicine and other industries.
Check Digit Verification of cas no
The CAS Registry Mumber 4608-49-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,6,0 and 8 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 4608-49:
(6*4)+(5*6)+(4*0)+(3*8)+(2*4)+(1*9)=95
95 % 10 = 5
So 4608-49-5 is a valid CAS Registry Number.
4608-49-5Relevant articles and documents
A (+)-Larixol Congener with High Affinity and Subtype Selectivity toward TRPC6
H?fner, Stephanie,Burg, Finn,Kannler, Martina,Urban, Nicole,Mayer, Peter,Dietrich, Alexander,Trauner, Dirk,Broichhagen, Johannes,Schaefer, Michael
, p. 1028 - 1035 (2018)
Natural products have many health benefits, and their application can improve the quality of life. Recently, the diterpene (+)-larixol and its acetylated congeners demonstrated selective inhibition of the second-messenger-gated cation channel transient receptor potential canonical 6 (TRPC6) over its close isoforms TRPC3 and TRPC7. Building on this knowledge, we expanded these findings by chemical diversification of (+)-larixol mostly at position C6. Implementing high-throughput Ca2+ FLIPR screening assays and electrophysiological patch-clamp recordings, we showcase larixyl N-methylcarbamate, termed SH045, as a compound with nanomolar affinity and 13-fold subtype selectivity over TRPC3 in stably expressing HEK293 cells. Expanding on this finding, TRPC6 inhibition was also observed in rat pulmonary smooth muscle cells. Furthermore, treatment of isolated perfused lung preparations with SH045 led to a decrease in lung ischemia-reperfusion edema (LIRE), a life-threatening condition associated with TRPC6 that may occur after organ transplantation. Taken together, and given the inexpensive, straightforward, and scalable preparation of SH045, we report a TRPC6 blocker that holds promise for the translational treatment of LIRE.
