4622-38-2

Basic information

• Product Name: 2-iodobenzyliodide
• Synonyms: 2-iodobenzyliodide
• CAS NO: 4622-38-2
• Molecular Weight: 343.934
• Mol File: 4622-38-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-iodobenzyliodide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-iodobenzyliodide(4622-38-2)
• EPA Substance Registry System: 2-iodobenzyliodide(4622-38-2)

Safety Data

• Hazardous Substances Data: 4622-38-2(Hazardous Substances Data)

Upstream product

• 5159-41-1 2-iodobenzyl alcohol 
• 40400-13-3 2-Iodobenzyl bromide 
• 4646-69-9 benzocyclopropene 
• 183789-20-0 2-iodobenzyl methanesulfonate 
• 186656-76-8 2-iodo-1-(4-methylbenzenesulfonyloxymethyl)benzene 
• 59473-45-9 2-(chloromethyl)iodobenzene 

Downstream Products

• 146040-14-4 3,4-Bis-(2-iodo-benzyl)-cyclobut-3-ene-1,2-dione 
• 117499-70-4 2-(2-Iodo-benzyl)-2-methyl-cyclohex-3-enone 
• 173317-31-2 (E)-3-{2-[2-(2-Iodo-phenyl)-ethyl]-1-methyl-1H-indol-3-yl}-acrylic acid ethyl ester 
• 203112-84-9 6-(2-iodobenzyl)-2-cyclohexen-1-one 
• 203112-98-5 6-(2-iodobenzyl)-2-methyl-5-(2-propene)-2-cyclohexen-1-one 
• 341970-35-2 (N-tert-butoxycarbonyl-N-methyl)-2-iodobenzylamine 
• 341970-36-3 (N-tert-butoxycarbonyl-N-diphenylmethyl)-2-iodobenzylamine 
• 895582-17-9 2-chloro-1-[(2-iodophenyl)methyl]-1H-benzo[d]imidazole 
• 895582-10-2 methyl 4-({1-[(2-iodophenyl)methyl]-1H-benzo[d]imidazol-2-yl}sulfanyl)benzene-1-carboxylate 
• 895582-08-8 4-({1-[(2-iodophenyl)methyl]-1H-benzo[d]imidazol-2-yl}sulfanyl)benzene-1-carboxylic acid 
• 248-72-6 11H-benzo[4,5]imidazo[2,1-a]isoindole 

Relevant articles and documents

Development of the "diverted Heck" Reaction for the Synthesis of Five-Membered Rings

The "diverted Heck"reaction has been shown to be a potent method to synthesize cyclopropanes from electron-rich olefins and iodomethyl trifluoroborate. Nevertheless, it is not mechanistically limited to the three-membered rings. The synthesis of five-memb

Synthesis and evaluation of colletoic acid core derivatives

Cortisol homeostasis has been linked to the pathogenesis of metabolic syndrome (MetS), since it stimulates hepatic gluconeogenesis and adipogenesis. MetS is classified as a constellation of health conditions that increase the risk of type 2 diabetes and cardiovascular disease. Intracellular cortisol levels are regulated by 11β-hydroxysteroid dehydrogenase (type 1 and type 2) in a tissue dependent manner. The type 1 enzyme (11β-HSD1) is widely expressed in glucocorticoid targeted tissues and is responsible for the conversion of cortisone to the active cortisol. Local reduction of cortisol regeneration presents a potential strategy for MetS treatment. Recently we disclosed the total synthesis of (+)-colletoic acid as a potent 11β-HSD1 inhibitor. Herein, we describe our improved processing chemistry for the synthesis of the colletoic acid core to access a diverse number of derivatives for evaluation against 11β-HSD1. The Evan's chiral auxiliary was utilized to construct the acyclic precursor 12 to afford the acorane core 9 using a modified Heck reaction in excellent chemical yields. The colletoic acid core derivatives showed modest activity against 11β-HSD1 and will serve for further biological evaluation.

Synthetic applications of aryl radical building blocks for cyclisation onto azoles

2-(2-Bromophenyl)ethyl groups have been used as building blocks in radical cyclisation reactions onto azoles to synthesise tri- and tetra-cyclic heterocycles. 2-(2-Bromophenyl)ethyl methanesulfonate was used to alkylate azoles (imidazoles, pyrroles, indol