4623-12-5

Basic information

• Product Name: 2-amino-N-{[(2-benzoyl-4-chlorophenyl)amino]acetyl}acetamide
• CAS NO: 4623-12-5
• Molecular Formula: C₁₇H₁₆ClN₃O₃
• Molecular Weight: 345.7802
• Mol File: 4623-12-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 624.4°C at 760 mmHg
• Flash Point: 331.4°C
• Density: 1.354g/cm³
• Vapor Pressure: 1.65E-15mmHg at 25°C
• Refractive Index: 1.637
• CAS DataBase Reference: 2-amino-N-{[(2-benzoyl-4-chlorophenyl)amino]acetyl}acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-N-{[(2-benzoyl-4-chlorophenyl)amino]acetyl}acetamide(4623-12-5)
• EPA Substance Registry System: 2-amino-N-{[(2-benzoyl-4-chlorophenyl)amino]acetyl}acetamide(4623-12-5)

Safety Data

• Hazardous Substances Data: 4623-12-5(Hazardous Substances Data)

Usage

Type of compound

Amide derivative

Constituent groups

Benzoyl group, chlorophenyl group, amino group, and acetyl group

Amino group attachment

Acetamide functional group

Acetyl group attachment

Amino group of the benzoylphenyl moiety

Application

Pharmaceutical research and development

Potential use

Study of new drugs and therapies, organic synthesis, and medicinal chemistry

Property variability

Specific properties and potential uses may vary depending on the context and goals of research or application.

Upstream product

• 59215-61-1 2-benzoyl-4-chloro-N^α-(tritylglycyl)glycinanilide 

Relevant articles and documents

Peptidoaminobenzophenones, a novel class of ring-opened derivatives of 1,4-benzodiazepines

A series of novel peptidoaminobenzophenones has been prepared via several routes and was evaluated for CNS activity. The structure-activity relationships in the series are discussed. In general, dipeptido-N-methylaminobenzophenones showed higher activities than the corresponding NH derivatives. Some compounds had very high activities in antipentylenetetrazole and antifighting tests in mice when orally administered. Very weak toxicity was also found in these compounds. Water solubility of the peptidoaminobenzophenones and their salts were tested. Possible in vivo conversion of peptidoaminobenzophenone by enzymatic cleavage of the terminal amino acid, followed by chemical cyclization to 1,4-benzodiazepine, is also discussed. Such novel open-ring derivatives of 1,4-benzodiazepine may serve as useful CNS agents.