46346-12-7

Basic information

• Product Name: Morpholine, 4-(2-phenylethyl)-
• CAS NO: 46346-12-7
• Molecular Formula: C12H17NO
• Molecular Weight: 191.273
• Mol File: 46346-12-7.mol
• Article Data: 34

Chemical Properties

• CAS DataBase Reference: Morpholine, 4-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Morpholine, 4-(2-phenylethyl)-(46346-12-7)
• EPA Substance Registry System: Morpholine, 4-(2-phenylethyl)-(46346-12-7)

Safety Data

• Hazardous Substances Data: 46346-12-7(Hazardous Substances Data)

Upstream product

• 18502-80-2 1,2-dimorpholino-1-phenyl ethane 
• 110-91-8 morpholine 
• 64-04-0 phenethylamine 
• 60-12-8 2-phenylethanol 
• 126200-24-6 4-(2-iodo-ethyl)-morpholine 
• 100-42-5 styrene 
• 110-89-4 piperidine 
• 39166-25-1 (E)-N-(2-phenylethenyl)morpholine 
• 5472-71-9 1-(4-morpholinomethyl)-1H-benzotriazole 
• 100-39-0 benzyl bromide 
• 77664-66-5 4-(2,2,2-trichloro-1-phenyl-ethyl)-morpholine 
• 28493-54-1 benzyltributyltin 
• 52853-19-7 N-(methylene)morpholinium chloride 
• 18811-63-7 N-(ethoxymethyl)morpholine 

Downstream Products

• 1312343-49-9 2-benzyl-4-phenethylmorpholine 
• 7469-58-1 4-(3-nitro-phenacyl)-4-phenethyl-morpholinium; bromide 
• 6277-94-7 4-phenacyl-4-phenethyl-morpholinium; bromide 
• 6274-06-2 4-phenethyl-4-(4-phenyl-phenacyl)-morpholinium; bromide 

Relevant articles and documents

Mechanistic studies of ruthenium-catalyzed anti-Markovnikov hydroamination of vinylarenes: Intermediates and evidence for catalysis through π-arene complexes

Studies are described that reveal the steps of the anti-Markovnikov hydroamination of vinylarenes with alkylamines catalyzed by Ru(COD)(2-methylallyl)2, bis(diphenylphosphino)pentane, and TfOH. Treatment of the catalyst components with an exces

B(C6F5)3-catalyzed tandem protonation/deuteration and reduction of: In situ -formed enamines

A highly efficient B(C6F5)3-catalyzed tandem protonation/deuteration and reduction of in situ-formed enamines in the presence of water and pinacolborane was developed. Regioselective β-deuteration of tertiary amines was achieved with high chemo- and regioselectivity. D2O was used as a readily available and cheap source of deuterium. Mechanistic studies indicated that B(C6F5)3 could activate water to promote the protonation and reduction of enamines. This journal is

Synthesis of Arylethylamines via C(sp3)-C(sp3) Palladium-Catalyzed Cross-Coupling

Substituted arylethylamines represent a key structural motif in natural, pharmaceutical, and agrochemical compounds. Access to such scaffolds has been the subject of long-standing synthetic interest. Herein, we report the synthesis of such scaffolds via a palladium-catalyzed C(sp3)-C(sp3) coupling between (chloromethyl)aryls and air-/moisture-stable N,N-dialkylaminomethyltrifluoroborate salts. Rapid hit identification was achieved using microscale high-throughput experimentation and was followed by millimolar-scale reaction parameter optimization. A range of structurally and electronically varied arylethylamine products were obtained in moderate to excellent yields (27-96%, >60 examples). The reaction mechanism is proposed to proceed via formation of a trialkylbenzylammonium species prior to oxidative addition.