4637-46-1Relevant articles and documents
Direct amidation of carboxylic acids with amines under microwave irradiation using silica gel as a solid support
Ojeda-Porras, Andrea,Hernández-Santana, Alejandra,Gamba-Sánchez, Diego
supporting information, p. 3157 - 3163 (2015/05/27)
A highly improved and green methodology for the direct amidation of carboxylic acids with amines using silica gel as a solid support and catalyst is described. The scope of this method is exemplified by the use of several aliphatic, aromatic, unsaturated and fatty acids. The reaction is also applied to different primary and secondary amines. Typically, the amines should be aliphatic, but aromatic amines can be used as well, though with lower yields. Several experiments to illustrate the selectivity of this methodology were also carried out with several more functionalized acids and amines. This approach is a substantial improvement over other previously described methods in amide synthesis.
Indium-mediated mild and facile method for the synthesis of amides
Cho, Dae Hyan,Jang, Doo Ok
, p. 2285 - 2287 (2007/10/03)
Indium-mediated coupling reactions of acyl chlorides and amines for the synthesis of amide bonds are described. The reaction afforded high yields of the desired amides under mild and neutral conditions, and it was applicable also to the preparation of peptides without epimerization.
