4640-42-0Relevant articles and documents
Synthesis and antimalarial activity of quinones and structurally-related oxirane derivatives
Carneiro, Paula F.,Pinto, Maria C.R.F.,Marra, Roberta K.F.,Da Silva, Fernando De C.,Resende, Jackson A.L.C.,Rocha E Silva, Luiz F.,Alves, Hilkem G.,Barbosa, Gleyce S.,De Vasconcellos, Marne C.,Lima, Emerson S.,Pohlit, Adrian M.,Ferreira, Vitor F.
, p. 134 - 140 (2015/12/04)
A series of eighteen quinones and structurally-related oxiranes were synthesized and evaluated for in vitro inhibitory activity against the chloroquine-sensitive 3D7 clone of the human malaria parasite Plasmodium falciparum. 2-amino and 2-allyloxynaphthoquinones exhibited important antiplasmodial activity (median inhibitory concentrations (IC50) 10 μM). Oxiranes 6 and 25, prepared respectively by reaction of α-lapachone and tetrachloro-p-quinone with diazomethane in a mixture of ether and ethanol, exhibited the highest antiplasmodial activity and low cytotoxicity against human fibroblasts (MCR-5 cell line). The active compounds could represent a good prototype for an antimalarial lead molecule.
Low hue photodisinfectants
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, (2008/06/13)
Low hue photo disinfecting compositions comprising organosilicon(IV) phthalocyanine and naphthalocyanines having Q-band absorption maxima at wavelengths greater than 660 nm and increased triplet state yields whereby production of singlet oxygen is increas
Octa-alkoxy Phthalocyanine and Naphthalocyanine Derivatives: Dyes with Q-band Absorption in the Far Red or Near Infrared
Cook, Michael J.,Dunn, Adrian J.,Howe, Steven D.,Thomson, Andrew J.,Harrison, Kenneth J.
, p. 2453 - 2458 (2007/10/02)
The lithium alkoxide-catalysed cyclic tetramerisation of various 3,6-dialkoxy-4,5-dichlorophthalonitriles, 1,4-dialkoxynaphthalene-2,3-dicarbonitriles and 3,6-dialkoxyphthalonitriles to give the corresponding metal-free octa-alkoxyoctachlorophthalocyanines, octa-alkoxynaphthalocyanines and octa-alkoxyphthalocyanines is described.An unexpected trans-alkoxylation reaction occurs during the cyclisation of the first two series of precursors.Metal-free phthalocyanines and naphthalocyanines have been converted into derivatives containing various metal ions.Compounds show Q-band absorption in the region 739-862 nm in toluene solution.The fluorescence spectra of selected examples are reported.The solubility of some of the compounds has been measured in a formulation of liquid crystal materials.