4640-77-1

Basic information

• Product Name: METHYL 3-(BUTYLAMINO)PROPANOATE
• Synonyms: METHYL 3-(BUTYLAMINO)PROPANOATE
• CAS NO: 4640-77-1
• Molecular Formula: C₈H₁₇NO₂
• Molecular Weight: 159.23
• Mol File: 4640-77-1.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 75 °C(Press: 5 Torr)
• Appearance: /
• Density: 0.9268 g/cm3(Temp: 21 °C)
• PKA: 9.09±0.19(Predicted)
• CAS DataBase Reference: METHYL 3-(BUTYLAMINO)PROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-(BUTYLAMINO)PROPANOATE(4640-77-1)
• EPA Substance Registry System: METHYL 3-(BUTYLAMINO)PROPANOATE(4640-77-1)

Safety Data

• Hazardous Substances Data: 4640-77-1(Hazardous Substances Data)

Upstream product

• 109-73-9 N-butylamine 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 1028560-07-7 C₂₉H₄₁N₃O₅S 
• 1431557-77-5 C₁₇H₂₃N₃O₂ 
• 1431558-10-9 C₂₄H₃₁N₃O₃ 
• 1431558-09-6 C₂₁H₃₃N₃O₃ 
• 1431558-08-5 C₁₉H₂₉N₃O₃ 
• 1431558-07-4 C₁₈H₂₇N₃O₃ 
• 1431558-03-0 C₂₉H₃₉N₃O₅ 
• 1431558-02-9 C₂₆H₄₁N₃O₅ 
• 1431558-01-8 C₂₄H₃₇N₃O₅ 
• 1431558-00-7 C₂₃H₃₅N₃O₅ 
• 1431557-95-7 C₂₂H₃₃N₃O₅ 
• 1431557-91-3 C₁₇H₂₅N₃O₃ 
• 1431557-88-8 C₁₉H₂₉NO₇S 
• 1431557-85-5 C₁₈H₂₇NO₅ 

Relevant articles and documents

Polymer coated magnetically separable organocatalyst for C[sbnd]N bond formation via aza-Michael addition

A polyacrylamide coated magnetite (PAM@MNP) catalyst was synthesized by following a two step approach involving the reaction of magnetite (Fe3O4) particles with coupling agent 3-(trimethoxysilyl)propyl methacrylate followed by grafting of acrylamide and subsequent polymerization via surface initiated radical polymerization technique. The synthesized organocatalyst was used for a one-pot aza-Michael addition reaction of amines with electron deficient alkenes to give β-amino carbonyls. The magnetic properties of the synthesized organocatalyst provide it a facile recovery by external magnet which eliminates the problems arising during catalyst separation by conventional filtration.

Aza-Michael reaction: Selective mono- versus bis-addition under environmentally-friendly conditions

Aza-Michael reactions between primary amines and methyl propenoate have been investigated under environmentally-friendly solventless heterogeneous catalysis in order to obtain the mono- or the bis-adduct. The reaction conditions can be altered so as to maximise the yields of the required product with high selectivity.

Synthesis of tetrahydropyrazolo[1,5- C ]pyrimidine-2,7(1 H,3 H)-diones

A series of tetrahydropyrazolo[1,5-c]pyrimidine-2,7(1H,3H)-diones 3a-h as the first representatives of the so far unexplored saturated heterocyclic system have been synthesized, formally in 12 steps from methyl acrylate (4). The synthesis comprises a four-step preparation of methyl N-Cbz-5-alkylamino-3- oxopentanoates 9a-c, their three-step transformation into 5-{2-[(alkyl) (benzyloxycarbonyl)amino]ethyl}pyrazolidin-3-ones 12a-c, three-step selective alkylation of the amidic N-2 to give 2-alkyl-5-{2-[(alkyl)(benzyloxycarbonyl) amino]ethyl}pyrazolidin-3-ones 16b-h, followed by hydrogenolytic Cbz-deprotection and subsequent cyclization of the intermediate 1,4-diamine with CDI to furnish the title compounds 3. Most of the synthetic steps were performed as a one-pot transformation. Georg Thieme Verlag Stuttgart New York.