46459-93-2Relevant articles and documents
Binding of 2,4-substituted morpholines at human D4 dopamine receptors
Showell, Graham A.,Emms, Frances,Marwood, Rosemarie,O'Connor, Desmond,Patel, Smita,Leeson, Paul D.
, p. 1 - 8 (2007/10/03)
The synthesis of a series of 2,4-disubstituted morpholines is described and their affinities at human dopamine receptors reported. The orally bioavailable 7-azaindole compound 11 has nanomolar affinity at the hD4 receptor with > 1000-fold selectivity over the hD2 receptor.
