46502-61-8 Usage
Description
1-Isoquinolineacetic acid ethyl ester, also known as ethyl 1-isoquinolineacetate, is a chemical compound belonging to the class of isoquinoline derivatives. It is an important building block in organic synthesis and is commonly used in the pharmaceutical industry as a key intermediate in the synthesis of various bioactive compounds, including antiviral and antitumor agents. This colorless liquid possesses a sweet, floral odor and is soluble in organic solvents such as ethanol and ether. Its properties make it ideal for use in the manufacturing of pharmaceuticals and other fine chemicals. Additionally, 1-Isoquinolineacetic acid ethyl ester has been studied for its potential applications in medicinal chemistry due to its ability to modulate biological targets and pathways. Overall, this compound is important for its role in the development of various therapeutic agents and has implications for the pharmaceutical industry and drug discovery.
Uses
Used in Pharmaceutical Industry:
1-Isoquinolineacetic acid ethyl ester is used as a key intermediate in the synthesis of various bioactive compounds for its role in the development of therapeutic agents.
Used in Medicinal Chemistry:
1-Isoquinolineacetic acid ethyl ester is used as a modulator of biological targets and pathways for its potential applications in drug discovery and the advancement of pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 46502-61-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,6,5,0 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 46502-61:
(7*4)+(6*6)+(5*5)+(4*0)+(3*2)+(2*6)+(1*1)=108
108 % 10 = 8
So 46502-61-8 is a valid CAS Registry Number.
InChI:InChI=1/C13H13NO2/c1-2-16-13(15)9-12-11-6-4-3-5-10(11)7-8-14-12/h3-8H,2,9H2,1H3
46502-61-8Relevant articles and documents
Studies on Pyrimidine Derivatives. XXXVIII. Cross-Coupling Reaction of N-Heteroaryl Iodides with Ethoxycarbonylmethylzinc Bromide in the Presence of Palladium Catalyst
Yamanaka, Hiroshi,An-naka, Masayuki,Kondo, Yoshinori,Sakamoto, Takao
, p. 4309 - 4313 (2007/10/02)
In the presence of tetrakis(triphenylphosphine)palladium, 2-iodo-4,6-dimethylpyrimidine and 4-iodo-2,6-dimethylpyrimidine reacted with ethoxycarbonylmethylzinc bromide (Reformatsky reagent) to give ethyl 4,6-dimethyl-2-pyrimidineacetate and ethyl 2,6-dimethyl-4-pyrimidineacetate, respectively.In contrast, the reaction of 5-iodo-2,4-dimethylpyrimidine with the same reagent resulted in recovery of the starting iodide.Similar results were observed in the reactions of various N-heteroaryl iodides.Keywords - Reformatsky reagent; cross-coupling reaction; N-heteroaryl halide; N-heteroarylacetic acid; palladium catalyst; ethyl bromoacetate
