4652-35-1

Basic information

• Product Name: 3-METHOXYACROLEIN
• Synonyms: 3-methoxy-2-propena;3-methoxy-2-propenal;3-methoxy-acrolei;beta-methoxy-acrolein;3-METHOXYACROLEIN;3-Methoxyacrylaldehyde
• CAS NO: 4652-35-1
• Molecular Formula: C₄H₆O₂
• Molecular Weight: 86.09
• Mol File: 4652-35-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 14-15 °C
• Boiling Point: 138.3°C at 760 mmHg
• Flash Point: 42.9°C
• Appearance: /
• Density: 0.937g/cm³
• Vapor Pressure: 6.77mmHg at 25°C
• Refractive Index: 1.406
• CAS DataBase Reference: 3-METHOXYACROLEIN(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHOXYACROLEIN(4652-35-1)
• EPA Substance Registry System: 3-METHOXYACROLEIN(4652-35-1)

Safety Data

• Statements: 11-25-26-34
• Safety Statements: 3/7-9-26-36/37/39
• RIDADR: 2924
• Hazardous Substances Data: 4652-35-1(Hazardous Substances Data)

Usage

Usage

Used in the production of flavors, fragrances, and pharmaceuticals.

Physical State

Reactive and highly flammable liquid.

Odor

Sweet, fruity odor.

Applications

Building block in the synthesis of various organic compounds.
Ingredient in pharmaceutical drugs and agrochemicals.
Flavoring agent in food products.
Fragrance ingredient in perfumes and cosmetics.

Hazards

May cause irritation to the skin and eyes.
Potential respiratory issues.
Can lead to lung damage.

Precautions

Proper handling and precautions required during use.

InChI:InChI=1/C4H6O2/c1-6-4-2-3-5/h2-4H,1H3/b4-2+

Upstream product

• 67-56-1 methanol 
• 624-67-9 Propargylic aldehyde 
• 122-31-6 malondialdehyde bis(diethyl acetal) 
• 79-22-1 methyl chloroformate 
• 14112-76-6 1-bromo-3,3-dimethoxy-propene 
• 999-66-6 3-methoxycarbonyloxy-propenal 

Downstream Products

• 68-35-9 sulfadiazine 
• 498-62-4 3-thiophene carboxaldehyde 
• 497866-09-8 3-(4-chloro-2-fluoro-5-((2-oxo-1,2-dihydropyridin-3-yl)oxy)phenyl)-1-methyl-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

The synthesis of 3-spirooxindole derivatives. Total syntheses of dl-formosanine, dl-isoformosanine, dl-mitraphylline and dl-isomitraphylline

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Synthesis and Diels-Alder reactions of (E)-6,6-dimethoxy-3-hexen-2-one

Treatment of 3,3-dimethoxypropanal (2) with (acetylmethylene)triphenylphosphorane (4) gives (E)-6,6-dimethoxy-3-hexen-2-one (5).Reaction of 5 with cyclopentadiene, 1,3-cyclohexadiene, anthracene, and 1,3-diphenylisobenzofuran gives Diels-Alder adducts, which on hydrolysis are converted to the corresponding keto aldehydes.Attempts to effect intramolecular aldol condensation of the latter were unsuccessful.Hydrolysis of the exo-acetyl adduct from 1,3-diphenylisobenzofuran with aqueous formic acid gives 4-acetyl-2,3,3a,4,5,9b-hexahydro-5,9b-diphenylnaphthofuran-2,5-diol, via aldehyde formation and hydrolytic cleavage of the ether bridge.The adduct from cyclopentadiene under anhydrous acid conditions give 3-acetyl-9-methoxy-tetracyclo2,4.03,7>nonane (27).