465520-07-4

Basic information

• Product Name: (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol
• Synonyms: (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol
• CAS NO: 465520-07-4
• Molecular Weight: 371.411
• Mol File: 465520-07-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol(465520-07-4)
• EPA Substance Registry System: (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methanol(465520-07-4)

Safety Data

• Hazardous Substances Data: 465520-07-4(Hazardous Substances Data)

Upstream product

• 556801-40-2 1-(2-fluoro-4 nitrophenyl)-4-phenylpiperazine 
• 478079-57-1 3-fluoro-4-(4-phenylpiperazin-1-yl)aniline 
• 369-34-6 3,4-difluoronitrobenzene 
• 92-54-6 4-phenyl-1-piperazine 
• 60456-26-0 (R)-glycidyl butyrate 
• 556801-41-3 N-benzyloxycarbonyl-3-fluoro-4-(4-phenylpiperazinyl)aniline 

Downstream Products

• 556801-43-5 (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl phthalimide 
• 465520-11-0 (S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 735276-50-3 (S)-N-[[3-(3-fluoro-4-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl]amine 
• 556801-42-4 (R)-[N-3-(3'-fluoro-4'-(4-phenylpiperazinyl)phenyl)-2-oxo-5-oxazolidinyl]methyl methanesulfonate 

Relevant articles and documents

Preparation method of oxazolidinone compound

The invention provides a preparation method of an oxazolidinone compound, particularly relates to a novel preparation method of (S)-[N-3-(3-fluorine-4-(4-phenyl piperazinyl) phenyl)-2-oxo-5-oxazolidinyl] methylacetamide, and relates to the medical field. According to the existing preparation method, the reagent selection effect is non ideal, so that the existing preparation method is high in post-treatment operation difficulty, low in yield and unfavorable for industrial expansion. All the steps are improved; use of raw materials with relatively high toxicity is avoided, and better reagents and a treatment process which is easier to operate are selected; the product yield is greatly increased; the process is more stable and favorable for industrial production.

CERTAIN CRYSTALLINE HYDRATES, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR PREPARATION AND USE THEREOF

At least one crystalline hydrate of (S)-[N-3-(3'-fluoro-4'-(4''-phenyl piperazinyl)) phenyl-2-oxo-5-oxazolidinyl] methyl acetamide, such as those with the following formula, wherein y is a number ranging from 1/12 to 1. Also provided are methods for the preparation of such crystalline hydrates, pharmaceutical compositions comprising such crystalline hydrates, and methods for their uses.