466-69-3

Basic information

• Product Name: 1,20-didehydro-1,22-dihydrostrychnidin-10-one
• CAS NO: 466-69-3
• Molecular Formula: C₂₁H₂₂N₂O₂
• Molecular Weight: 334.4116
• Mol File: 466-69-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 579°C at 760 mmHg
• Flash Point: 304°C
• Density: 1.42g/cm³
• Vapor Pressure: 2.11E-13mmHg at 25°C
• Refractive Index: 1.724
• CAS DataBase Reference: 1,20-didehydro-1,22-dihydrostrychnidin-10-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,20-didehydro-1,22-dihydrostrychnidin-10-one(466-69-3)
• EPA Substance Registry System: 1,20-didehydro-1,22-dihydrostrychnidin-10-one(466-69-3)

Safety Data

• Hazardous Substances Data: 466-69-3(Hazardous Substances Data)

Usage

Chemical class

Alkaloid

Source

Plant Strychnos nux-vomica

Common use

Pesticide and rodenticide

Structure

Complex and intricate, containing multiple ring systems and functional groups

Toxicity

Potent neurotoxin

Regulation

Highly regulated, use restricted to licensed professionals

Handling

Must be handled with extreme caution due to potential harm to human and animal health.

Upstream product

• 6882-83-3 10-carboxy-19-methyl-9,10-seco-C-nor-strychnidinium; betaine 
• 56-23-5 tetrachloromethane 
• 57-24-9 strychnidin-10-one 

Downstream Products

• 15006-14-1 19,20-dihydrostrychnine 

Relevant articles and documents

Structure-activity relationships of strychnine analogs at glycine receptors

Nine strychnine derivatives including neostrychnine, strychnidine, isostrychnine, 21,22-dihydro-21-hydroxy-22-oxo-strychnine, and several hydrogenated analogs were synthesized, and their antagonistic activities at human α1 and α1β glycine receptors were evaluated. Isostrychnine has shown the best pharmacological profile exhibiting an IC 50 value of 1.6μM at α1 glycine receptors and 3.7-fold preference towards the α1 subtype. SAR Analysis indicates that the lactam moiety and the C(21) C(22) bond in strychnine are essential structural features for its high antagonistic potency at glycine receptors Copyright