466-85-3Relevant articles and documents
Probing the pharmacophore for allosteric ligands of muscarinic M 2 receptors: SAR and QSAR studies in a series of bisquaternary salts of caracurine V and related ring systems
Zlotos, Darius P.,Buller, Stefan,Stiefl, Nikolaus,Baumann, Knut,Mohr, Klaus
, p. 3561 - 3571 (2007/10/03)
Allosteric effects on muscarinic acetylcholine M2 receptors were examined in a series of bisquaternary salts of the Strychnos alkaloid caracurine V (6) and related iso-caracurine V, tetrahydrocaracurine V, and bisnortoxiferine ring systems. The
Total synthesis of (-)-strychnine via the Wieland - Gumlich aldehyde
Sole, Daniel,Bonjoch, Josep,Garcia-Rubio, Silvina,Peidro, Emma,Bosch, Joan
, p. 395 - 397 (2007/10/03)
Fifteen steps suffice for an enantioselective total synthesis of (-)- strychnine (1) from 1,3-cyclohexanedione. The key steps are the easy generation of the enantiopure intermediate 2, the closure of the piperidine ring by a reductive Heck reaction, and the elaboration of the indoline nucleus in an advanced synthetic stage. TBDMS = tert-butyldimethylsilyl.
Enantioselective total synthesis of (-)-strychnine
Knight,Overman,Pairaudeau
, p. 9293 - 9294 (2007/10/02)
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