4667-74-7

Basic information

• Product Name: 4,5-dimethoxy-1H-isoindole-1,3(2H)-dione
• Synonyms: 1H-isoindole-1,3(2H)-dione, 4,5-dimethoxy-; 4,5-Dimethoxy-1H-isoindole-1,3(2H)-dione
• CAS NO: 4667-74-7
• Molecular Formula: C₁₀H₉NO₄
• Molecular Weight: 207.1828
• Mol File: 4667-74-7.mol
• Article Data: 2

Chemical Properties

• Density: 1.331g/cm³
• Refractive Index: 1.566
• CAS DataBase Reference: 4,5-dimethoxy-1H-isoindole-1,3(2H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dimethoxy-1H-isoindole-1,3(2H)-dione(4667-74-7)
• EPA Substance Registry System: 4,5-dimethoxy-1H-isoindole-1,3(2H)-dione(4667-74-7)

Safety Data

• Hazardous Substances Data: 4667-74-7(Hazardous Substances Data)

Upstream product

• 79622-66-5 1-Chlor-4,5-dimethoxy-isobenzofuran-3-on 
• 519-05-1 opianic acid 
• 25984-84-3 3-[1-[2-(2-Dimethylamino-ethyl)-4,5-dimethoxy-phenyl]-meth-(Z)-ylidene]-6,7-dimethoxy-2,3-dihydro-isoindol-1-one 

Downstream Products

• 5701-87-1 3,4-dimethoxyanthranilic acid 
• 5653-51-0 6-amino-2,3-dimethoxybenzoic acid 
• 153356-79-7 (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-1-carboxy-1-methyl-ethoxyimino]-acetylamino}-3-(4-bromo-6,8-dioxo-2,2-diphenyl-6,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-7-ylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 153356-78-6 (6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-1-carboxy-1-methyl-ethoxyimino]-acetylamino}-3-(6,8-dioxo-2,2-diphenyl-6,8-dihydro-[1,3]dioxolo[4,5-e]isoindol-7-ylmethyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 153356-77-5 4-Bromo-6,8-dioxo-2,2-diphenyl-6,8-dihydro-[1,3]dioxolo[4,5-e]isoindole-7-carboxylic acid ethyl ester 
• 153356-76-4 N-carboethoxy diphenylmethylenedioxyphthalimide 
• 153356-75-3 4-Bromo-2,2-diphenyl-[1,3]dioxolo[4,5-e]isoindole-6,8-dione 
• 153356-74-2 diphenylmethylenedioxyphthalimide 
• 462085-17-2 4,5-dimethoxy-2-{2-[6-(4-methoxy-benzyloxymethyl)-benzo[1,3]dioxol-5-yl]-ethyl}-isoindole-1,3-dione 
• 518-90-1 3,4-dimethoxy-phthalic acid 
• 7664-41-7 ammonia 

Relevant articles and documents

Hydroxylamine and pseudoacyl systems: Pseudo-oximes

Unhindered furan pseudoacyl chlorides react with hydroxylamine and a carbonate base to form oxidized cyclic N-hydroxyiminoimides. Thus, 3-chloroisobenzofuran-1-one forms 3-hydroximinoisoindolin-1-one (4) C 8H6N2O2. Molecules are nearly planar and E-secondary amides hydrogen-bond with oximes through N(H)...N 2.920 A and O(H)...O 2.720 A contacts, and form infinite chains. Mucochloryl chloride (2,3,4-trichlorodihydrofuran-1-one) forms a similar hydroxyiminoimide (5E)-3,4-dichloro-5-hydroxyiminopyrrol-2-one (6), C 4H2Cl2N2O2. However, opianic acid forms a mixture of mostly N-hydroxyphthalimide [6,7-dimethoxy-N- hydroxyisoindolin-1,3-dione (9)], C10H10N 2O2, with small amounts of open oxime carboxylate [potassium 2,3-dimethoxy-6-(N-hydroxymethanoyl)benzoate (8) C10H 10NO5K], and 2,3-dimethoxyphthalimide (10), C 10H9NO4. These results suggest an intermediate pseudo-oxime, and such a derivative has been made in quantitative yield in a dehydration resistant arylpyran pseudoacyl system. 3-Chloro-4,4- dimethylisobenzopyran-1-one reacts with two equivalents of hydroxylamine and a carbonate base to form 2-hydroxy-3-(hydroxyamino)-4,4-dimethyl-3H-isoquinolin-1- one (14), C11H13N2O3, a pseudo-oxime. Pairs of pseudo-oximes form four hydrogen-bonds in two complementary sets, with N(H)...O 3.008 A and O(H)...O 2.685 A. Molecules are also linked in chains by hydrogen-bonds with O(H)...O 2.696 A. These products have been characterized by spectroscopy and X-ray diffraction. Graphical Abstract: [Figure not available: see fulltext.].