4670-10-4

Basic information

• Product Name: 3,5-DIMETHOXYPHENYLACETIC ACID
• Synonyms: 3,5-DIMETHOXYPHENYLACETIC ACID;RARECHEM AL BO 0339;TIMTEC-BB SBB006648;3,5-Dimethoxy;(3,5-Dimethoxyphenyl)acetic acid,98%;Benzeneacetic acid, 3,5-diMethoxy-;3,5-Dimethoxybenzeneacetic acid;(3,5-Dimethoxyphenyl)acetic acid 98%
• CAS NO: 4670-10-4
• Molecular Formula: C₁₀H₁₂O₄
• Molecular Weight: 196.2
• Product Categories: Aromatic Phenylacetic Acids and Derivatives;Organic acids;Building Blocks for Dendrimers;Functional Materials;C10;Carbonyl Compounds;Carboxylic Acids
• Mol File: 4670-10-4.mol
• Article Data: 23

Chemical Properties

• Melting Point: 102-103 °C(lit.)
• Boiling Point: 293.08°C (rough estimate)
• Flash Point: 140.1 °C
• Appearance: brown powder
• Density: 1.2166 (rough estimate)
• Vapor Pressure: 1.4E-05mmHg at 25°C
• Refractive Index: 1.5430 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.08±0.10(Predicted)
• CAS DataBase Reference: 3,5-DIMETHOXYPHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIMETHOXYPHENYLACETIC ACID(4670-10-4)
• EPA Substance Registry System: 3,5-DIMETHOXYPHENYLACETIC ACID(4670-10-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-36/37
• Safety Statements: 26-36-36/37
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 4670-10-4(Hazardous Substances Data)

Usage

Description

3,5-Dimethoxyphenylacetic Acid, also known as (3,5-Dimethoxyphenyl)acetic acid, is a carboxylic acid with a brown powder appearance. It possesses unique chemical properties, including a specific density, freezing point, boiling point, and refractive index, which make it a versatile compound for various applications.

Uses

Used in Pharmaceutical Industry:
3,5-Dimethoxyphenylacetic Acid is used as a general reactant/reagent for the synthesis of a recyclable, immobilized analogue of Benzotetramisole. This application is significant in the development of new drugs and pharmaceutical compounds, potentially leading to advancements in the treatment of various medical conditions.
Used in Chemical Synthesis:
In the field of chemical synthesis, 3,5-Dimethoxyphenylacetic Acid serves as a valuable reactant due to its unique chemical properties. It can be utilized in the creation of various compounds and materials, contributing to the development of new products and technologies across different industries.
Used in Research and Development:
3,5-Dimethoxyphenylacetic Acid is also used in research and development settings, where its chemical properties can be explored and harnessed for the creation of novel compounds and materials. This can lead to breakthroughs in various scientific fields, including materials science, pharmaceuticals, and environmental science.

InChI:InChI=1/C10H12O4/c1-13-8-3-7(5-10(11)12)4-9(6-8)14-2/h3-4,6H,5H2,1-2H3,(H,11,12)/p-1

Upstream product

• 124-38-9 carbon dioxide 
• 56723-83-2 2-(3,5-dimethoxyphenyl)nitroethane 
• 86255-43-8 trans-1-(3,5-Dimethoxyphenyl)-2-nitroethylene 
• 1141493-97-1 tert-butyl 2-(3,5-dimethoxyphenyl)acetate 
• 365564-07-4 3,5-dimethoxyphenylboronic acid pinacol ester 
• 4179-19-5 1,3-dimethoxy-5-methylbenzene 
• 39151-19-4 1-(3,5-dimethoxyphenyl)ethan-1-one 
• 64118-89-4 Methoxyeugenol 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 17213-57-9 3,5-dimethoxybenzoyl chloride 
• 4670-09-1 2-(3,5-dihydroxyphenyl)acetic acid 
• 4724-10-1 methyl 2-(3,5-dihydroxyphenyl)acetate 
• 6652-32-0 3,5-dimethoxybenzylchloride 
• 7311-34-4 3,5-dimethoxybenzaldehdye 

Downstream Products

• 18917-77-6 (3,5-dimethoxyphenyl)acetone 
• 7417-20-1 3,5-dimethoxyphenethyl alcohol 
• 120078-23-1 1-(3,4-dimethoxyphenyl)-2-(3,5-dimethoxyphenyl)ethanone 
• 17275-78-4 2-Brom-3,5-dimethoxy-phenylessigsaeure-methylester 
• 17275-81-9 2,6-Dibrom-3,5-dimethoxy-phenylessigsaeure-methylester 
• 537-42-8 3,5-dimethoxy-4'-hydroxy-trans-stilbene 
• 135387-93-8 (S)-3-[(S)-2-Azido-2-(3,5-dimethoxy-phenyl)-acetyl]-4-benzyl-oxazolidin-2-one 
• 103889-87-8 (S)-3,5-dimethoxyphenylglycine 
• 103889-85-6 (R)-3,5-dimethoxyphenylglycine 
• 920007-18-7 7,8-dihydroxy-3-(3',5'-dimethoxyphenyl)coumarin 
• 1225530-30-2 (1S,5S)-5-methoxy-1-methyl-7-octenyl 2-(3,5-dimethoxyphenyl)acetate 
• 1247212-20-9 8-bromo-6-methyl-3-(3,5-dimethoxyphenyl)coumarin 
• 1266332-91-5 E-2-(3,5-dimethoxyphenyl)-3-(3,4-dimethoxyphenyl)acrylic acid 
• 1338596-76-1 3-(2-bromo-3,5-dimethoxyphenyl)-6-methylcoumarin 

Relevant articles and documents

Desulfonylative Electrocarboxylation with Carbon Dioxide

Electrocarboxylation of organic halides is one of the most investigated electrochemical approaches for converting thermodynamically inert carbon dioxide (CO2) into value-added carboxylic acids. By converting organic halides into their sulfone derivatives, we have developed a highly efficient electrochemical desulfonylative carboxylation protocol. Such a strategy takes advantage of CO2as the abundant C1 building block for the facile preparation of multifunctionalized carboxylic acids, including the nonsteroidal anti-inflammatory drug ibuprofen, under mild reaction conditions.

Stereoselective Total Synthesis of (-)-(2 S,4 R)-3′-Methoxyl Citreochlorol: Preparation and Use of New Proline-Based Auxiliary for Asymmetric Acetate Aldol Reaction

The first stereoselective total synthesis of (-)-(2S,4R)-3′-methoxy citreochlorol and (-)-(2S,4S)-3′-methoxy citreochlorol is demonstrated. A proline-based imidazolidinone was synthesized and used as chiral auxiliary for asymmetric acetate aldol reaction to generate initial chirality in the targeted molecule. Geminal dichloromethane functionality was introduced by the addition of in situ generated dichloromethyllithium to Weinreb's amide functional group.

Simple access to 5-carboalkoxy-2,3-dihydro-4H-pyran-4-ones via domino acylative electrocyclization: The first three step total synthesis of the dihydronaphthopyran-4-one class of natural products

Intermolecular domino C-acylation/6π-oxaelectrocyclization between β-ketoesters and α,β-unsaturated acid chlorides took place readily in the presence of CaCl2 to afford a variety of polysubstituted 5-carboalkoxy-2,3-dihydro-4H-pyran-4-ones, in good yields. The products were successfully exploited as precursors, for a simple and efficient construction of a naphthalene fused pyran-4-one ring system. This intramolecular Friedel-Crafts acylative aromatization approach was useful for the synthesis of the phytogrowth inhibiting dihydronaphthopyranone class of natural products.