467438-39-7

Basic information

• Product Name: Butanoic acid, 4,4-difluoro-2-[[(phenylmethoxy)carbonyl]amino]-, (2S)-
• Synonyms: Butanoic acid,4,4-difluoro-2-[[(phenylmethoxy)carbonyl]amino]-,(2S)
• CAS NO: 467438-39-7
• Molecular Formula: C12H13F2NO4
• Molecular Weight: 273.23300
• Mol File: 467438-39-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4,4-difluoro-2-[[(phenylmethoxy)carbonyl]amino]-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4,4-difluoro-2-[[(phenylmethoxy)carbonyl]amino]-, (2S)-(467438-39-7)
• EPA Substance Registry System: Butanoic acid, 4,4-difluoro-2-[[(phenylmethoxy)carbonyl]amino]-, (2S)-(467438-39-7)

Safety Data

• Hazardous Substances Data: 467438-39-7(Hazardous Substances Data)

Upstream product

• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 121960-22-3 α-amino-γ,γ-difluorobutyrate 

Downstream Products

• 928162-24-7 benzyl (S)-1-{[(cyclopropylsulfonyl)amino]carbonyl}-3-difluoropropylcarbamate 
• 484648-98-8 methyl 4-{2-[((2S)-2-{[(benzyloxy)carbonyl]amino}-4,4-difluorobutanoyl)amino]-ethyl}-3-chlorobenzoate 
• 484648-95-5 benzyl (1S)-1-({[2-(2-chlorophenyl)ethyl]amino}carbonyl)-3,3-difluoropropyl-carbamate 

Relevant articles and documents

Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: Discovery, initial SAR, and molecular modeling

The discovery of novel, reversible and competitive tripeptide inhibitors of the Hepatitis C virus NS3/4A serine protease is described. These inhibitors are characterized by the presence of a C-terminal phenethyl amide group, which extends into the prime side of the enzyme. Initial SAR together with molecular modeling and data from site-directed mutagenesis suggest an interaction of the phenethyl amide group with Lys-136.