4675-38-1

Basic information

• Product Name: 7 alpha,26-dihydroxy-4-cholesten-3-one
• Synonyms: 7 alpha,26-dihydroxy-4-cholesten-3-one;7alpha,26-dihydroxycholest-4-en-3-one
• CAS NO: 4675-38-1
• Molecular Formula: C27H44O3
• Molecular Weight: 416.6365
• Mol File: 4675-38-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 554.5°Cat760mmHg
• Flash Point: 303.2°C
• Appearance: /
• Density: 1.08g/cm³
• Vapor Pressure: 1.33E-14mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 7 alpha,26-dihydroxy-4-cholesten-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7 alpha,26-dihydroxy-4-cholesten-3-one(4675-38-1)
• EPA Substance Registry System: 7 alpha,26-dihydroxy-4-cholesten-3-one(4675-38-1)

Safety Data

• Hazardous Substances Data: 4675-38-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C27H44O3/c1-17(16-28)6-5-7-18(2)21-8-9-22-25-23(11-13-27(21,22)4)26(3)12-10-20(29)14-19(26)15-24(25)30/h14,17-18,21-25,28,30H,5-13,15-16H2,1-4H3/t17?,18-,21-,22+,23+,24-,25+,26+,27-/m1/s1

Upstream product

• 4725-24-0 5-cholesten-3β,7α,27-triol 

Relevant articles and documents

Analysis of derivatised steroids by matrix-assisted laser desorption/ionisation and post-source decay mass spectrometry

Neutral steroids are difficult to analyse using desorption ionisation methods coupled with mass spectrometry (MS). However, steroids with an unhindered ketone group can readily be derivatised with the Girard P (GP) reagent to give GP hydrazones. Steroid GP hydrazones contain a quaternary nitrogen atom and are readily desorbed in the matrix-assisted laser desorption/ionisation (MALDI) process, giving an improvement in sensitivity of two orders of magnitude. Steroids without a ketone group, but with a 3β-hydroxy-Δ5 function, can be readily converted to 3-oxo-Δ4 steroids and subsequently derivatised to GP hydrazones for MALDI analysis. In addition to giving strong [M]+ ions upon MALDI, steroid GP hydrazones give informative post-source decay (PSD) spectra. By using the accurate mass of the precursor-ion measured by MALDI-MS, in combination with the structural information encoded in its PSD spectrum, steroid structures can readily be determined.