4680-63-1 Usage
Derived from
Adenine
Structure
Purine base connected to a sugar moiety through a glycosidic bond, thiol group at position 6 of the purine ring
Biological role
Plays a role in RNA and DNA modification
Therapeutic applications
Studied for potential anti-cancer and anti-viral treatments
Mechanisms of action
Inhibits nucleic acid synthesis, disrupts nucleoside metabolism
Potential uses
Development of new nucleoside analog drugs for various medical conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 4680-63-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,6,8 and 0 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 4680-63:
(6*4)+(5*6)+(4*8)+(3*0)+(2*6)+(1*3)=101
101 % 10 = 1
So 4680-63-1 is a valid CAS Registry Number.
4680-63-1Relevant articles and documents
Facile synthesis of 5'-deoxy- and 2',5'-dideoxy-6-thiopurine nucleosides by nucleoside phosphorylases
Chae, Whi-Gun,Chan, Thomas C. K.,Chang, Ching-Jer
, p. 8661 - 8670 (1998)
5'-Deoxy-6-thioguanosine, 2',5'-dideoxy-6-thioguanosine, 5'-deoxy-6- mercaptopurine riboside and 2',5'-dideoxy-6-mercaptopurine riboside were synthesized enzymatically from thiopurine bases and corresponding ribosyl donors using nucleoside phosphorylase. This is the first report of trans-5'- deoxyribosylation to thiopurine bases by nucleoside phosphorylase. 5'-Deoxy- 6-thioguanosine selectively blocked the growth of v-ras-transformed human bronchial epithelial cells. In addition, the in vitro antitumor cytotoxicity data for 5'-deoxy- and 2',5'-dideoxy-6-thiopurine nucleosides were comparable to those for the corresponding thiopurine bases.
