468075-00-5

Basic information

• Product Name: 2-BROMO-1-CHLORO-4-(TRIFLUOROMETHOXY)BENZENE
• Synonyms: 2-Bromo-1-chloro-4-(trifluoromethoxy)benzen;3-BroMo-4-chloro-1-(trifluoroMethoxy)benzene
• CAS NO: 468075-00-5
• Molecular Formula: C₇H₃BrClF₃O
• Molecular Weight: 275.45
• Product Categories: Fluorine series
• Mol File: 468075-00-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 205℃
• Flash Point: 78℃
• Appearance: /
• Density: 1.743
• Vapor Pressure: 0.366mmHg at 25°C
• Refractive Index: 1.493
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-BROMO-1-CHLORO-4-(TRIFLUOROMETHOXY)BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-CHLORO-4-(TRIFLUOROMETHOXY)BENZENE(468075-00-5)
• EPA Substance Registry System: 2-BROMO-1-CHLORO-4-(TRIFLUOROMETHOXY)BENZENE(468075-00-5)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 468075-00-5(Hazardous Substances Data)

Usage

General Description

2-Bromo-1-chloro-4-(trifluoromethoxy)benzene is a synthetic organic compound with the molecular formula C7H4BrClF3O. It is a derivative of fluorobenzene with bromine, chlorine and a trifluoromethoxy group attached to the benzene ring. 2-Bromo-1-chloro-4-(trifluoromethoxy)benzene is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is known to have several industrial applications, including use as a building block in the production of various organic compounds. Additionally, it has been identified as a potential environmental contaminant and may pose a risk to human health and the environment, as it is considered to be a moderately hazardous substance.

InChI:InChI=1/C7H3BrClF3O/c8-5-3-4(1-2-6(5)9)13-7(10,11)12/h1-3H

Upstream product

• 544-16-1 n-Butyl nitrite 
• 175278-17-8 2-bromo-4-trifluoromethoxyaniline 

Downstream Products

• 1599479-01-2 rac-ethyl 2-(3-(2-chloro-5-(trifluoromethoxy)phenyl)-3-azaspiro[5.5 ]undec-9-yl)propanoate 

Relevant articles and documents

GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE

Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

Pyrido[4,3- e ][1,2,4]triazolo[4,3- a ]pyrazines as selective, brain penetrant phosphodiesterase 2 (PDE2) inhibitors

A novel series of pyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrazines is reported as potent PDE2/PDE10 inhibitors with drug-like properties. Selectivity for PDE2 was obtained by introducing a linear, lipophilic moiety on the meta-position of the phenyl ring pending from the triazole. The SAR and protein flexibility were explored with free energy perturbation calculations. Rat pharmacokinetic data and in vivo receptor occupancy data are given for two representative compounds 6 and 12.