46864-14-6

Basic information

• Product Name: (1S,2R)-N,N-dimethyl-2-hydroxy-1,2-diphenyl-ethylamine
• Synonyms: (1S,2R)-N,N-dimethyl-2-hydroxy-1,2-diphenyl-ethylamine
• CAS NO: 46864-14-6
• Molecular Weight: 241.333
• Mol File: 46864-14-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (1S,2R)-N,N-dimethyl-2-hydroxy-1,2-diphenyl-ethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,2R)-N,N-dimethyl-2-hydroxy-1,2-diphenyl-ethylamine(46864-14-6)
• EPA Substance Registry System: (1S,2R)-N,N-dimethyl-2-hydroxy-1,2-diphenyl-ethylamine(46864-14-6)

Safety Data

• Hazardous Substances Data: 46864-14-6(Hazardous Substances Data)

Upstream product

• 50-00-0 formaldehyd 
• 23190-16-1 (1R,2S)-2-Amino-1,2-diphenylethanol 
• 64-18-6 formic acid 
• 550-58-3 (1S,2S)-1,2-diphenyl-2-(N-methyl)aminoethanol 
• 506-59-2 N,N-dimethylammonium chloride 
• 1689-71-0 cis-1,2-diphenyloxirane 
• 574-13-0 benzoin E-oxime 
• 98340-87-5 ((1RS,2SR)-2-hydroxy-1,2-diphenyl-ethyl)-trimethyl-ammonium; iodide 
• 530-36-9 erythro-2-amino-1,2-diphenylethanol 
• 74-88-4 methyl iodide 

Downstream Products

• 50-00-0 formaldehyd 

Relevant articles and documents

Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines

Potassium fluoride (KF) is an ideal reagent for fluorination because it is safe, easy to handle and low-cost. However, poor solubility in organic solvents coupled with limited strategies to control its reactivity has discouraged its use for asymmetric C-F

Synthesis and reactivities of enantiomerically pure β hydroxyalkyl and β-aminoalkyl ferrocenyl sulfides

Enantiomerically pure β-hydroxyalkyl and β-aminoalkyl ferrocenyl sulfides have been synthesized in good yields from mercaptoferrocene and amino alcohol derivatives. Primary β-aminoalkyl sulfides allowed the synthesis of tetrahydro-1,4-thiazepines containing the ferrocene moiety with good diastereoselectivity and β-iminoalkyl sulfides. Some of these derivatives have successfully been employed as ligands for palladium-catalyzed allylic substitution, with asymmetric induction of up to 99% ee. ( Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002).

Optical Resolution of 2-Amino-1,2-diphenylethanol by Preferential Crystallization and Its Utilization in Fractional Crystallization and Enantioselective Reduction of Prochiral Ketones

(-/+)-erythro-2-Amino-1,2-diphenylethanol prepared from benzoin oxime by catalytic reduction was successfully resolved into pair of optically active forms by preferential crystallization.The optically active amino alcohol was found to be useful as a basic resolving agent for optical resolution of tartaric acid, trans-2,3-oxiranedicarboxylic acid, 2-hydroxy-2-phenylpropionic acid, and 3-endo-benzamido-5-norbornene-2-endo-carboxylic acid.Chiral hydrides prepared from lithium aluminium hydride and optical active threo- and erythro-2-amino-1,2-diphenylethanol derivatives were applied to the enantioface differentiating reduction of prochiral ketones to give the corresponding optically active alcohols in the 26-72percent optical purities.