469-59-0 Usage
Description
Jervine is an alkaloid first obtained from Veratrum grandiflorum and also present in V. album. It is a white crystalline solid with various chemical properties and derivatives. Jervine has been found to have vasodilatory effects, causing a drop in blood pressure in large doses.
Uses
1. Used in Pharmaceutical Applications:
Jervine is used as a starting material for C-nor-D-homosteroids due to its unique chemical structure and properties.
2. Used in Research and Development:
Jervine is used as a research compound for studying its teratogenic properties and its ability to induce holoprosencephaly and block endogenous Sonic hedgehog signaling.
3. Used in Antibacterial Applications:
Jervine is used as an antibacterial agent due to its antimicrobial properties.
Purification Methods
4 Crystallise Jervine from MeOH/H2O or Me2O. The hydrochloride has m 300-302o (from MeOH/Et2O), and the picrate has m 26
References
Wright, Luff., J. Chern. Soc., 35,405 (1879)
Saltzberger., Arch. Pharrn., 228,462 (1890)
Bredemann., Apoth. Zeit., 21,41,53 (1906)
Saito, Suginome, Takaoka., Bull. Chern. Soc. Japan, 9, 15(1934)
Saito, Suginome, Takaoka., ibid, 11, 168, 172 (I936)
Poethke., Arch. Pharrn., 357,571 (I937)
Poethke., ibid, 276, 170 (1938)
Jacobs, Craig., J. BioI. Chern., 148, 51 (1943)
Seiferle.,J. Econ. Entorn., 35,35 (1942)
Jacobs et al., J. Bioi. Chern., 170, 635 (1947)
Wintersteiner et al., J. A mer. Chern. Soc., 73, 2970 (1951)
Wintersteiner, Hosansky., ibid, 74,4474 (1952)
Stereochemistry:
Kupchan, Suffness., J. A mer. Chern. Soc., 90, 2730 (1968)
Masamune et al., Tetrahedron, 24, 3461 (1968)
Check Digit Verification of cas no
The CAS Registry Mumber 469-59-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 469-59:
(5*4)+(4*6)+(3*9)+(2*5)+(1*9)=90
90 % 10 = 0
So 469-59-0 is a valid CAS Registry Number.
InChI:InChI=1/C27H39NO3/c1-14-11-21-24(28-13-14)16(3)27(31-21)10-8-19-20-6-5-17-12-18(29)7-9-26(17,4)23(20)25(30)22(19)15(27)2/h5,14,16,18-21,23-24,28-29H,6-13H2,1-4H3/t14-,16+,18-,19-,20-,21+,23+,24-,26-,27-/m0/s1
