46921-20-4 Usage
Description
L-Histidine Benzyl Ester is a derivative of the amino acid Histidine, characterized by the presence of a benzyl ester group. L-Histidine Benzyl Ester exhibits unique biochemical properties and serves as a versatile intermediate in the synthesis of various complex molecules.
Uses
Used in Pharmaceutical Industry:
L-Histidine Benzyl Ester is used as an enzyme inhibitor for sweet-almond β-glucosidase, yeast α-glucosidase, and Escherichia coli β-galactosidase. Its inhibitory action on these enzymes plays a crucial role in the development of therapeutic agents targeting specific metabolic pathways.
Used in Chemical Synthesis:
L-Histidine Benzyl Ester is used as an intermediate in the synthesis of more complex compounds, such as Remikiren (R143550). Its unique structure allows for the creation of a wide range of pharmaceuticals and other specialty chemicals, expanding its applications across various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 46921-20-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,6,9,2 and 1 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 46921-20:
(7*4)+(6*6)+(5*9)+(4*2)+(3*1)+(2*2)+(1*0)=124
124 % 10 = 4
So 46921-20-4 is a valid CAS Registry Number.
46921-20-4Relevant articles and documents
A class of novel conjugates of substituted purine and Gly-AA-OBzl: Synthesis and evaluation of orally analgesic activity
Kang, Guifeng,Zhao, Ming,Zhang, Xiaoyi,Peng, Li,Li, Chunbo,Mao, Wei,Ye, Weidong,Peng, Shiqi
supporting information; experimental part, p. 6157 - 6160 (2010/12/19)
Aimed at the chemotherapy of chronic pain two kinds of analgesic pharmacophores, substituted purine and Gly-AA-OBzl, were coupled via a five-step-reaction procedure and 19 novel conjugates N-[2-chloro-9- (tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycylamino acid benzylesters were provided. On mouse-tail flick model their in vivo analgesic activities were assayed. The results indicate that introducing Gly-OC2H 5 into the 6-position of the substituted purine leads to ambiguous increase of the analgesic activity, while introducing Gly-AA-OBzl into this position leads to significant increase of the analgesic activity.