470-12-2 Usage
Description
Cladinose, also known as 3,6-dideoxy-D-arabino-hexose, is a monosaccharide sugar that is commonly associated with the macrolide ring of certain antibiotics. It is a hexose sugar with a unique structure, characterized by the absence of two oxygen atoms at the third and sixth positions. Cladinose is a light yellow oil at room temperature and possesses distinct chemical properties that make it useful in various applications.
Uses
Used in Pharmaceutical Industry:
Cladinose is used as a component in the development of macrolide antibiotics for its ability to enhance the efficacy and pharmacokinetic properties of these drugs. The addition of cladinose to the macrolide ring improves the solubility, absorption, and distribution of the antibiotic in the body, leading to better treatment outcomes for bacterial infections.
Used in Drug Delivery Systems:
Cladinose can be utilized as a component in the design of drug delivery systems, particularly for macrolide antibiotics. Its unique chemical properties allow for the development of novel drug formulations that can improve the bioavailability, stability, and targeted delivery of the active pharmaceutical ingredients.
Used in Chemical Research:
As a monosaccharide with a distinct structure, cladinose can be employed in chemical research to study the interactions between sugars and other biomolecules. This can lead to a better understanding of carbohydrate chemistry and the development of new compounds with potential applications in various industries, including pharmaceuticals, agriculture, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 470-12-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 0 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 470-12:
(5*4)+(4*7)+(3*0)+(2*1)+(1*2)=52
52 % 10 = 2
So 470-12-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H16O4/c1-6(10)7(11)8(2,12-3)4-5-9/h5-7,10-11H,4H2,1-3H3/t6-,7-,8+/m0/s1
470-12-2Relevant articles and documents
Theoretical and experimental investigation on clarithromycin, erythromycin A and azithromycin and descladinosyl derivatives of clarithromycin and azithromycin with 3-O substitution as anti-bacterial agents
Arsic, Biljana,Awan, Abida,Brennan, Richard J.,Aguilar, Juan A.,Ledder, Ruth,McBain, Andrew J.,Regan, Andrew C.,Barber, Jill
supporting information, p. 1347 - 1354 (2014/11/08)
Erythromycin A, clarithromycin and azithromycin are the three most important macrolide antibiotics and are all very widely used in the clinic. They act on the bacterial ribosome inhibiting protein synthesis. We have performed both NMR (transferred NOESY) and modelling studies in order to determine the conformations of these antibiotics when they are bound to ribosomes. All three drugs exhibit the folded-out conformation in the bound state, but the dominant conformation of azithromycin is not completely superimposable on the clarithromycin and erythromycin A 9-ketone structures. Modelling suggests that clarithromycin (based on a 14-membered ring) and its 3-O-substituted descladinosyl derivatives are conformationally rigid molecules; these are compounds which generally exhibit more activity against Gram-positive bacteria. Azithromycin (based on a 15-membered ring) and its 3-O-descladinosyl derivatives are flexible in silico and show more activity against Gram-negative bacteria in culture.
