4704-77-2Relevant articles and documents
HALONIUM ION-INDUCED BIOSYNTHESIS OF CHLORINATED MARINE METABOLITES
Geigert, John,Neidleman, Saul L.,Witt, Susanne K. de,Dalietos, Demetrios J.
, p. 287 - 290 (1984)
Bromoperoxidases do not directly oxidize the chloride ion; nevertheless, in the presence of bromide ions, chloride ions and hydrogen peroxide, bromoperoxidases react with alkenes and alkynes to produce bromochloro-derivatives.This same reaction is catalysed when seawater is the source of chloride and bromide ions.This suggests that bromonium ion-induced biosynthesis of chlorinated metabolites occurs in marine environments.The role of iodonium ions in the biosynthesis of chlorinated metabolites is also discussed.Key Word Index - Coralina sp.; Rhodophyta; biological halogenation; bromoperoxidase; enzymatic bromochlorination; marine chlorination; role of bromonium ions and iodonium ions; seawater.
Bromotrimethylsilane as a selective reagent for the synthesis of bromohydrins
Giomi, Donatella,Salvini, Antonella,Ceccarelli, Jacopo,Brandi, Alberto
, p. 14453 - 14458 (2021/05/19)
Bromotrimethylsilane (TMSBr) is a very efficient reagent in the solvent-free conversion of glycerol into bromohydrins, useful intermediates in the production of fine chemicals. As glycerol is a relevant by-product in biodiesel production, TMSBr has been also tested as a mediator in transesterification in acidic conditions, providing FAME from castor oil in good yields, along with bromohydrins from glycerol. Subsequently the glycerol conversion was optimized and depending on the reaction conditions, glycerol can be selectively converted into α-monobromohydrin (1-MBH) or α,γ-dibromohydrin (1,3-DBH) in very good yields. This journal is
USES AND COMPOSITIONS OF NITRATE ESTERS FOR PROVIDING SEDATION
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, (2008/06/13)
Use of certain nitrate ester compounds or pharmaceutically acceptable salts thereof in the manufacture of a medicament for treating pain or providing analgesia.
Studies into reactions of N-methylmorpholine-N-oxide (NMMO) and its hydrates with cyanuric chloride
Rosenau, Thomas,Potthast, Antje,Kosma, Paul
, p. 9809 - 9815 (2007/10/03)
The course of the reaction between N-methylmorpholine-N-oxide (NMMO, 1a) and cyanuric chloride (2) is strictly dependent on the hydrate water content of the amine oxide. In solid phase, both substances undergo an explosion-like, extremely exothermic reaction. In solution, this process becomes controllable and leads to a quantitative degradation of NMMO into morpholine and formaldehyde, with 2 only acting as an inducing agent. The reaction can be conducted in a way that a clean deoxygenative demethylation is achieved. The monohydrate of NMMO (1b) is quantitatively converted into N-methylmorpholine and hypochlorous acid by the action of 2. This conversion can be used in synthesis either to deoxygenate tertiary amine N-oxide monohydrates, or to produce chlorohydrins in non-aqueous, organic media in superior yields. The semisesquihydrate of NMMO (1c) reacts with 2 under consumption of water until non-hydrated NMMO is present, which is then further converted into morpholine and HCHO, as in the case of 1a being directly employed as the starting material.
