470463-35-5

Basic information

• Product Name: 2-CHLORO-3-TRIMETHYLSILANYLETHYNYL-PYRIDINE
• Synonyms: 2-CHLORO-3-TRIMETHYLSILANYLETHYNYL-PYRIDINE;2-chloro-3-[(triMethylsilyl)ethynyl]pyridine;2-(2-chloropyridin-3-yl)ethynyl-trimethylsilane
• CAS NO: 470463-35-5
• Molecular Formula: C₁₀H₁₂ClNSi
• Molecular Weight: 209.75
• Mol File: 470463-35-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 253.7°Cat760mmHg
• Flash Point: 107.2°C
• Appearance: /
• Density: 1.07g/cm³
• Vapor Pressure: 0.0287mmHg at 25°C
• Refractive Index: 1.519
• CAS DataBase Reference: 2-CHLORO-3-TRIMETHYLSILANYLETHYNYL-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-3-TRIMETHYLSILANYLETHYNYL-PYRIDINE(470463-35-5)
• EPA Substance Registry System: 2-CHLORO-3-TRIMETHYLSILANYLETHYNYL-PYRIDINE(470463-35-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 470463-35-5(Hazardous Substances Data)

Usage

General Description

2-Chloro-3-trimethylsilanylethynyl-pyridine is an organosilicon compound with the chemical formula C10H11ClNSi. It is a white to light yellow colored liquid with a pungent odor. 2-Chloro-3-trimethylsilanylethynyl-pyridine is primarily used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a reagent in organic synthesis and as an intermediate in the production of functional materials. The compound is known to be toxic if ingested or inhaled and should be handled with caution.

InChI:InChI=1/C10H12ClNSi/c1-13(2,3)8-6-9-5-4-7-12-10(9)11/h4-5,7H,1-3H3

Upstream product

• 52200-48-3 3-bromo-2-chloropyridine 
• 1066-54-2 trimethylsilylacetylene 
• 78607-36-0 2-chloro-3-iodopyridine 

Downstream Products

• 1196156-69-0 2-chloro-3-ethynylpyridine 
• 485385-76-0 3-ethynyl-2-phenylpyridine 
• 485385-81-7 2-phenyl-3-(trimethylsilylethynyl)pyridine 

Relevant articles and documents

Pd(0)-catalyzed domino C-N coupling/hydroamination/C-H arylation reactions: Efficient synthesis and photophysical properties of azaindolo[1,2-f]phenanthridines

A series of new 7- and 4-azaindolo[1,2-f]phenanthridines were synthesized by a domino Pd(0)-catalyzed reaction, which involves three sequential steps: C-N coupling, hydroamination, and intramolecular C-H arylation. The products show promising fluorescence properties with high quantum yields (12-65%).

CONDENSED HETEROAROMATIC RING SYSTEMS. VII. SYNTHESIS OF THIENOPYRIDINES, THIENOPYRIMIDINES, AND FUROPYRIDINES FROM o-SUBSTITUTED N-HETEROARYLACETYLENES

The cross-coupling reaction of 2-chloro-3-iodo- and 4-chloro-3iodopyridines with phenylacetylene in the presence of dichlorobis(triphenylphosphine)palladium occured at the 3-position.The 3-ethynylpyridines containing an adjacent chloro group were converti