4706-33-6

Basic information

• Product Name: OXO-PIPERIDIN-1-YL-ACETIC ACID
• Synonyms: OXO-PIPERIDIN-1-YL-ACETIC ACID;1-piperidineacetic acid, alpha-oxo-;oxo(1-piperidinyl)acetic acid(SALTDATA: FREE);2-keto-2-piperidino-acetic acid;2-oxo-2-(1-piperidyl)acetic acid;2-oxo-2-piperidin-1-ylacetic acid;2-oxo-2-piperidin-1-yl-ethanoic acid;oxo(1-piperidinyl)acetic acid
• CAS NO: 4706-33-6
• Molecular Formula: C₇H₁₁NO₃
• Molecular Weight: 157.17
• Mol File: 4706-33-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 295.6°C at 760 mmHg
• Flash Point: 132.6°C
• Appearance: /
• Density: 1.273g/cm³
• Vapor Pressure: 0.000366mmHg at 25°C
• Refractive Index: 1.518
• CAS DataBase Reference: OXO-PIPERIDIN-1-YL-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: OXO-PIPERIDIN-1-YL-ACETIC ACID(4706-33-6)
• EPA Substance Registry System: OXO-PIPERIDIN-1-YL-ACETIC ACID(4706-33-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 4706-33-6(Hazardous Substances Data)

Usage

General Description

OXO-PIPERIDIN-1-YL-ACETIC ACID, also known as piperidin-1-yl acetic acid, is a chemical compound with the molecular formula C8H15NO3. It is a derivative of piperidine and acetic acid and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. OXO-PIPERIDIN-1-YL-ACETIC ACID is known for its role as a building block in the production of various drugs, especially antihistamines and analgesics. It is a white crystalline powder that is soluble in water and organic solvents, and it is commonly used in laboratory research and chemical manufacturing processes.

InChI:InChI=1/C7H11NO3/c9-6(7(10)11)8-4-2-1-3-5-8/h1-5H2,(H,10,11)

Upstream product

• 110-89-4 piperidine 
• 95-92-1 oxalic acid diethyl ester 
• 20173-02-8 methyl 2-oxo-2-(piperidine-1-yl)acetate 
• 15029-30-8 1-cyanoacetylpiperidine 
• 7732-18-5 water 
• 53074-96-7 ethyl 2-oxo-2-(piperidine-1-yl)acetate 
• 4755-77-5 Ethyl oxalyl chloride 

Downstream Products

• 272773-62-3 3,4-dioxo-4-piperidino-2-(1,1,1-triphenyl-Λ⁵-phosphanylidene)butanenitrile 
• 1350443-93-4 C₂₄H₂₉NO₅ 
• 776-75-0 N-benzoylpiperidine 
• 13939-69-0 piperidine carbamoyl chloride 
• 2591-86-8 N-Formylpiperidine 

Relevant articles and documents

Direct C3 Carbamoylation of 2H-Indazoles

We developed a novel method for direct C3 carbamoylation of 2H-indazoles using oxamic acids as carbamoyl radical sources. In the presence of ammonium persulfate, carbamoyl radicals were generated from oxamic acids, then used for further reactions with 2H-indazoles to afford the desired products. The reaction proceeds under metal- and catalyst-free conditions. This simple process allows for the efficient synthesis of C3 carbamoylated 2H-indazoles, which are important scaffolds in organic synthesis.

Metal-, Photocatalyst-, and Light-Free Direct C-H Acylation and Carbamoylation of Heterocycles

Direct C-H acylations and carbamoylations of heterocycles can now be readily achieved without requiring any conventional metal, photocatalyst, electrocatalysis, or light activation, thus significantly improving on sustainability, costs, toxicity, waste, and simplicity of the operational procedure. These mild conditions are also suitable for gram-scale reactions and late-stage functionalizations of complex molecules, including pharmaceuticals, N,N-ligands, and light-sensitive molecules.

A model β-sheet interaction and thermodynamic analysis of β-strand mimetics

β-Sheet mediated protein-protein interactions are involved in key signalling pathways in diseases such as cancer. We present small molecule β-strand mimetics and investigate their interactions with a model tripeptide. Using 1H NMR, the thermodynamic parameters for their binding are determined. These give insight into this biologically important interaction.