4712-63-4 Usage
Description
1-(2-deoxyhexopyranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione, commonly known as thymidine, is a nucleoside chemical compound that serves as a fundamental building block of DNA. It consists of a deoxyhexopyranosyl group attached to a 5-methylpyrimidine-2,4(1H,3H)-dione moiety. Thymidine is vital for DNA replication and repair, as it is integrated into the DNA strand during synthesis, ensuring the genetic integrity of the cell. It also holds potential therapeutic applications in cancer and viral infection treatments and is utilized in biochemical research for synthesizing labeled nucleotides for DNA sequencing and molecular biology techniques.
Uses
Used in Biochemical Research:
Thymidine is used as a precursor in biochemical research for the synthesis of labeled nucleotides, which are essential for DNA sequencing and other molecular biology techniques. Its incorporation into DNA allows for the tracking and analysis of genetic material, providing valuable insights into various biological processes.
Used in Pharmaceutical Applications:
1-(2-deoxyhexopyranosyl)-5-methylpyrimidine-2,4(1H,3H)-dione is used as a therapeutic agent in the treatment of certain types of cancer and viral infections. Its role in DNA replication and repair makes it a promising candidate for targeting cancer cells and inhibiting viral replication, potentially leading to novel treatment strategies.
Used in Diagnostic Applications:
In the field of diagnostics, thymidine can be employed as a marker for monitoring cellular processes related to DNA synthesis. Its incorporation into DNA can be used to assess the rate of cell proliferation and DNA repair, which may be indicative of various pathological conditions or responses to therapeutic interventions.
Used in Drug Development:
Thymidine's role in DNA synthesis and its potential therapeutic applications make it a valuable compound in the development of new drugs targeting cancer and viral infections. Researchers can leverage its properties to design novel therapeutic agents that interfere with DNA replication and repair, potentially leading to the development of more effective treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 4712-63-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,1 and 2 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 4712-63:
(6*4)+(5*7)+(4*1)+(3*2)+(2*6)+(1*3)=84
84 % 10 = 4
So 4712-63-4 is a valid CAS Registry Number.
4712-63-4Relevant articles and documents
Synthesis of 3′-azido-2′,3′Dideoxy-4′-ketohexopyranoid analogues as possible antiviral nucleosides
Khan, Abdul R.,Mulligan, Kimberly X.,Redda, Kinfe K.,Ollapally, Abraham P.
, p. 1023 - 1030 (2007/10/03)
Peracetylated 2-deoxy-D-glucose was coupled with silylated bases. The product was deacetylated and the 4′,6′-hydroxy groups were then protected. An azido group was introduced at the 3′-carbon via tosylation, followed by deprotection, tritylation, and oxid
