4721-22-6Relevant articles and documents
Dynamics within a single molecular layer. Aggregation, relaxation, and the absence of motion
Horne,Blanchard
, p. 12788 - 12795 (1996)
We report on the transient and steady-state optical responses of the chromophore 2,2′-bithiophene-5,5′-diylbis(phosphonic acid) (BDP) incorporated within a single zirconium-phosphonate layer as a function of chromophore density. While the dilute solution optical response of BDP reveals no anomalous behavior, its characteristics are substantially different when confined within a monolayer. We vary the concentrations of layer constituents to determine the extent of interaction between BDP moieties within a single monolayer. We observe limited initial aggregation of BDP, the extent of which is determined largely by the conditions under which the monolayer is formed. Over time, the fractional contribution of BDP aggregates to the total optical response decreases to a limiting value, implicating surface adsorption site density as the dominant factor in determining the morphology of the organobis(phosphonate) layer. Motional relaxation measurements of BDP within the layer show that the chromophores are immobile on the hundreds-of-picoseconds time scale of our experiments.
Rapid one-pot synthesis of alkane-α ω, diylbisphosphonic acids from dihalogenoalkanes under microwave irradiation
Villemin, Didier,Moreau, Bernard,Kaid, M'Hamed,Didi, Mohamed Amine
experimental part, p. 1583 - 1586 (2010/10/01)
A one-pot, two-step synthesis of alkylenebisphosphonic acids from dihalogenoalkanes was performed under microwave irradiation. The reaction is very rapid and convenient for the synthesis of small samples of alkylenebisphosphonic acids. Copyright Taylor & Francis Group, LLC.
Highly potent bisphosphonate ligands for phosphoglycerate kinase
Jakeman, David L.,Ivory, Andrew J.,Williamson, Michael P.,Blackburn, G. Michael
, p. 4439 - 4452 (2007/10/03)
We have synthesized a series of novel analogs of 1,3-bisphospho-D- glyceric acid, 1,3-BPG, and evaluated their binding to phosphoglycerate kinase, PGK (EC 2.7.2.3). Nonscissile methanephosphonic acids replace the two phosphate monoesters of 1,3-BPG and lead to several stable, tight-binding mimics of this intermediate species in glycolysis. Multiple fluorine substitution for hydrogen in the α-methylene groups of the phosphonic acid 1,3-BPG analogs markedly improves their binding to PGK as determined by NMR analysis. The best ligands bind some 50-100 times more strongly than does the substrate 3-phospho-D-glyceric acid and show a requirement for pK(a)3 to be generally below 6.0, while the presence of a β-carbonyl group seems to be of secondary importance.
