47292-84-2Relevant articles and documents
Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines
Yearick, Kimberly,Ekoue-Kovi, Kekeli,Iwaniuk, Daniel P.,Natarajan, Jayakumar K.,Alumasa, John,De Dios, Angel C.,Roepe, Paul D.,Wolf, Christian
, p. 1995 - 1998 (2008)
Systematic variation of the branching and basicity of the side chain of chloroquine yielded a series of new 7-chloro-4-aminoquinoline derivatives exhibiting high in vitro activity against four different strains of P. falciparum. Many of the compounds test