473530-15-3

Basic information

• Product Name: 5-phenyl-3-[1-(toluene-4-sulphonyl)-hex-5-ynyl]-1,2,4-triazine
• Synonyms: 5-phenyl-3-[1-(toluene-4-sulphonyl)-hex-5-ynyl]-1,2,4-triazine
• CAS NO: 473530-15-3
• Molecular Weight: 391.494
• Mol File: 473530-15-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-phenyl-3-[1-(toluene-4-sulphonyl)-hex-5-ynyl]-1,2,4-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-phenyl-3-[1-(toluene-4-sulphonyl)-hex-5-ynyl]-1,2,4-triazine(473530-15-3)
• EPA Substance Registry System: 5-phenyl-3-[1-(toluene-4-sulphonyl)-hex-5-ynyl]-1,2,4-triazine(473530-15-3)

Safety Data

• Hazardous Substances Data: 473530-15-3(Hazardous Substances Data)

Upstream product

• 7569-26-8 chloromethyl p-tolylsulfone 
• 18162-28-2 5-phenyl-1,2,4-triazine 
• 2468-55-5 5-iodopent-1-yne 
• 473530-09-5 5-phenyl-3-(toluene-4-sulphonylmethyl)-1,2,4-triazine 

Relevant articles and documents

Tandem vicarious nucleophilic substitution of hydrogen/intramolecular Diels-Alder reaction of 1,2,4-triazines into functionalized cycloalkenopyridines1

Synthesis of 2,3- and 3,4-cyclopentenopyridines, 5,6,7,8- tetrahydroquinolines and 5,6,7,8-tetrahydroisoquinolines from 1,2,4-triazine derivatives is reported. Introduction of an α-functionalized methyl substituent (e.g. arylsulphonyl, sulphonamide, sulphonic acid ester) into position 3- or 6- of triazines by vicarious nucleophilic substitution of hydrogen and subsequent alkylation with alkyl iodides bearing an acetylenic function in terminal position afforded valuable intermediates for intramolecular Diels-Alder reaction with inverse electron demand. When heated at higher temperature, these triazine derivatives gave the Diels-Alder cycloadducts, which, after spontaneous extrusion of nitrogen moiety, led to a variety of functionalized cycloalkenopyridine derivatives.