473719-41-4

Basic information

• Product Name: AMG 487
• Synonyms: AMG 487;N-[(1R)-1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide
• CAS NO: 473719-41-4
• Molecular Formula: C32H28F3N5O4
• Molecular Weight: 603.5910296
• Mol File: 473719-41-4.mol
• Article Data: 3

Chemical Properties

• Melting Point: 161.2℃ (ethyl acetate heptane )
• Appearance: /
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• CAS DataBase Reference: AMG 487(CAS DataBase Reference)
• NIST Chemistry Reference: AMG 487(473719-41-4)
• EPA Substance Registry System: AMG 487(473719-41-4)

Safety Data

• Hazardous Substances Data: 473719-41-4(Hazardous Substances Data)

Usage

Description

AMG 487 is a selective and potent antagonist of the chemokine receptor CXCR3, which plays a crucial role in various immune responses and inflammatory processes.

Uses

Used in Pharmaceutical Industry:
AMG 487 is used as a therapeutic agent for the treatment of autoimmune and inflammatory diseases. By selectively blocking the CXCR3 receptor, it modulates the immune response and reduces inflammation, offering potential benefits in managing conditions such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease.
Used in Research Applications:
AMG 487 is used as a research tool for studying the role of CXCR3 in immune responses and disease mechanisms. It helps researchers to understand the molecular pathways and interactions involved in various inflammatory and autoimmune conditions, facilitating the development of novel therapeutic strategies and drug targets.

Upstream product

• 5345-47-1 2-aminopyridin-3-carboxylic acid 
• 156-43-4 4-Ethoxyaniline 
• 752244-96-5 C₁₇H₁₈N₄O₂ 
• 752244-95-4 (R)-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-carbamic acid tert-butyl ester 
• 473720-90-0 (R)-{1-[3-(4-ethoxy-phenylcarbamoyl)-pyridin-2-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 473720-89-7 (R)-[1-(4-oxo-4H-pyrido[2,3-d][1,3]oxazin-2-yl)-ethyl]-carbamic acid tert-butyl ester 
• 473720-92-2 C₂₃H₂₃N₅O₂ 
• 4315-07-5 4-(trifluoromethoxy)phenylacetic acid 
• 947536-13-2 rac-2-(1-amino-ethyl)-3-(4-ethoxy-phenyl)-3H-pyrido[2,3-d]pyrimidin-4-one 
• 947536-02-9 rac-3-(4-ethoxy-phenyl)-2-{1-[(pyridin-3-ylmethyl)-amino]-ethyl}-3H-pyrido[2,3-d]pyrimidin-4-one 

Relevant articles and documents

Synthesis and Application of the First Radioligand Targeting the Allosteric Binding Pocket of Chemokine Receptor CXCR3

Strategies for the identification of allosteric modulators of chemokine receptors largely rely on various cell-based functional assays. Radioligand binding assays are typically not available for allosteric binding sites. We synthesized, purified, and appl

Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists

CXC chemokine receptor-3 (CXCR3) is a G-protein coupled receptor (GPCR) predominantly expressed on activated T lymphocytes that promote Th1 responses. Previously, we described the 3H-quinazolin-4-one containing VUF 5834 (decanoic acid {1-[3-(4-cyano-pheny