473806-21-2

Basic information

• Product Name: (2S,4R)-4-BOC-AMINO PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCL
• Synonyms: (2S,4R)-methyl 4-(tert-butoxycarbonyl)pyrrolidine-2-carboxylate;(4R)-4-[[(1,1-Dimethylethoxy)carbonyl]amino]-L-Proline methyl ester;(2S,4R)-Methyl 4-(tert-butoxycarbonylaMino)pyrrolidine-2-carboxy;L-Proline,4-[[(1,1-diMethylethoxy)carbonyl]aMino]-, Methyl ester, (4R)-;O4-tert-Butyl O2-methyl (2S,4R)-pyrrolidine-2,4-dicarboxylate;(2S,4R)-METHYL 4-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE-2-CARBOXYLATE（WS203569）
• CAS NO: 473806-21-2
• Molecular Formula: C11H20N2O4
• Molecular Weight: 244.289
• Product Categories: Pharm intermediate
• Mol File: 473806-21-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 347.0±42.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 11.90±0.40(Predicted)
• CAS DataBase Reference: (2S,4R)-4-BOC-AMINO PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCL(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-BOC-AMINO PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCL(473806-21-2)
• EPA Substance Registry System: (2S,4R)-4-BOC-AMINO PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCL(473806-21-2)

Safety Data

• Hazardous Substances Data: 473806-21-2(Hazardous Substances Data)

Usage

General Description

(2S,4R)-4-BOC-AMINO PYRROLIDINE-2-CARBOXYLIC ACID METHYL ESTER-HCL is a chemical compound that is a methyl ester of (2S,4R)-4-BOC-amino pyrrolidine-2-carboxylic acid hydrochloride. It is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals and other complex molecules. The BOC (tert-butyloxycarbonyl) protecting group on the amino group of the pyrrolidine moiety makes it a versatile intermediate for the synthesis of diverse compounds. The hydrochloride salt form of this compound enhances its stability and solubility in a variety of solvents, making it easier to handle and use in synthetic processes.

Upstream product

• 189215-87-0 (2S,4S)-4-(4-Nitro-benzoyloxy)-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-methyl ester 
• 189215-88-1 1-benzyl 2-methyl (2S,4S)-4-((methylsulfonyl)oxy)pyrrolidine-1,2-dicarboxylate 
• 762233-34-1 1-benzyl 2-methyl (2S,4R)-4-aminopyrrolidine-1,2-dicarboxylate 
• 57653-35-7 (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylic acid 1-benzyl 2-methyl 
• 24424-99-5 di-tert-butyl dicarbonate 
• 13504-85-3 (2S,4R)-1-(benzyloxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid 
• 189215-89-2 (2S,4R)-N-1-(benzyloxycarbonyl)-4-azidoproline methyl ester 
• 64187-48-0 methyl (2S,4R)-1-benzyloxycarbonyl-4-hydroxypyrrolidine-2-carboxylate 
• 189215-90-5 1-benzyl 2-methyl (2S,4R)-4-(tert-butoxycarbonylamino)pyrrolidine-1,2-dicarboxylate 
• 77345-53-0 (2S,4S)-N-1-(benzyloxycarbonyl)-4-(p-toluenesulfonyloxy)proline methyl ester 
• 51-35-4 4R-4-hydroxyproline 

Downstream Products

• 273222-06-3 (2S,4R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonylamino)pyrrolidine-2-carboxylic acid 
• 189215-92-7 (2S,4R)-1-[2-(4-Benzyloxycarbonylamino-2-oxo-2H-pyrimidin-1-yl)-acetyl]-4-tert-butoxycarbonylamino-pyrrolidine-2-carboxylic acid methyl ester 

Relevant articles and documents

Two prolines with a difference: contrasting stereoelectronic effects of 4R/S-aminoproline on triplex stability in collagen peptides [pro(X)-pro(Y)-Gly]n.

4R/S-Aminoprolines when present in the X-position of collagen peptide [pro(X)-pro(Y)-Gly]n exhibit pH- and stereochemistry-dependent effects on triplex stability.