4740-77-6

Basic information

• Product Name: 2,6-dimethyl-1,3-dioxan-4-ol
• Synonyms: 2,6-dimethyl-1,3-dioxan-4-ol;Aldoxane;1,3-Dioxan-4-ol, 2,6-dimethyl-;Einecs 225-247-3
• CAS NO: 4740-77-6
• Molecular Formula: C₆H₁₂O₃
• Molecular Weight: 132.15768
• EINECS: 225-247-3
• Mol File: 4740-77-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 204.8 °C at 760 mmHg
• Flash Point: 77.6 °C
• Appearance: /
• Density: 1.052 g/cm³
• Vapor Pressure: 0.062mmHg at 25°C
• Refractive Index: 1.433
• CAS DataBase Reference: 2,6-dimethyl-1,3-dioxan-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-dimethyl-1,3-dioxan-4-ol(4740-77-6)
• EPA Substance Registry System: 2,6-dimethyl-1,3-dioxan-4-ol(4740-77-6)

Safety Data

• Hazardous Substances Data: 4740-77-6(Hazardous Substances Data)

Usage

Use

Solvent in chemical processes

Physical properties

Colorless liquid, mild sweet odor

Solubility

soluble in water and organic solvents

Applications

Synthesis of pharmaceuticals, agrochemicals, specialty chemicals
Reagent in organic chemistry reactions, particularly in carbon-carbon bond formation

InChI:InChI=1/C6H12O3/c1-4-3-6(7)9-5(2)8-4/h4-7H,3H2,1-2H3

Upstream product

• 151-50-8 potassium cyanide 
• 75-07-0 acetaldehyde 
• 109-89-7 diethylamine 
• 107-89-1 acetaldol 
• 7653-39-6 2-(2-hydroxypropyl)-4-hydroxy-6-methyl-1,3-dioxane 

Downstream Products

• 18826-95-4 1.3-butanediol 
• 24621-61-2 1,3-butanediol 
• 6290-03-5 (R)-butane-1,3-diol 
• 107-89-1 acetaldol 
• 75-07-0 acetaldehyde 
• 30907-38-1 4-benzoyloxy-2,6-dimethyl-[1,3]dioxane 
• 828-00-2 6-acetoxy-2,4-dimethyl-1,3-dioxane 

Relevant articles and documents

CONVERSION OF ALCOHOLS TO LINEAR AND BRANCHED FUNCTIONALIZED ALKANES

Embodiments herein concerns the eco-friendly conversion of simple alcohols to linear or branched functionalized alkanes, by integrated catalysis. The alcohols are firstlyoxidized either chemically or enzymatically to the corresponding aldehydes or ketones, followed by aldol condensations using a catalyst to give the corresponding enals or enones. The enals or enones are subsequently and selectively hydrogenated using a recyclable heterogeneous metal catalyst, organocatalyst or an enzyme to provide linear or branched functionalized alkanes with an aldehyde, keto- or alcohol functionality. The process is also iterative and can be further extended by repeating the above integrated catalysis for producing long-chain functionalized alkanes from simple alcohols.

One-Pot Synthesis of (S)-Baclofen via Aldol Condensation of Acetaldehyde with Diphenylprolinol Silyl Ether Mediated Asymmetric Michael Reaction as a Key Step

An efficient asymmetric total synthesis of (S)-baclofen was accomplished via a one-pot operation from commercially available materials using sequential reactions, such as aldol condensation of acetaldehyde, diphenylprolinol silyl ether mediated asymmetric Michael reaction of nitromethane, Kraus-Pinnick oxidation, and Raney Ni reduction. Highly enantioenriched baclofen was obtained in one pot with a good yield over four reactions.