4742-01-2

Basic information

• Product Name: N-AMINOPROPYL ANILINE
• Synonyms: N-AMINOPROPYL ANILINE;RARECHEM AL BW 0230;N-(3-Aminopropyl)aniline;N1-PHENYLPROPANE-1,3-DIAMINE
• CAS NO: 4742-01-2
• Molecular Formula: C₉H₁₄N₂
• Molecular Weight: 150.22
• Mol File: 4742-01-2.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-AMINOPROPYL ANILINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-AMINOPROPYL ANILINE(4742-01-2)
• EPA Substance Registry System: N-AMINOPROPYL ANILINE(4742-01-2)

Safety Data

• RIDADR: UN 2811 6.1 / PGIII
• Hazardous Substances Data: 4742-01-2(Hazardous Substances Data)

Upstream product

• 25112-12-3 2-cyano-N-phenyl-acetaldimine 
• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 62-53-3 aniline 
• 108-86-1 bromobenzene 
• 109-76-2 Trimethylenediamine 
• 156-87-6 propan-1-ol-3-amine 
• 115022-93-0 benzyl (3-oxo-3-(phenylamino)propyl)carbamate 
• 583-53-9 2,3-dibromobenzene 
• 108-36-1 1,3-dibromobenzene 
• 57528-64-0 3-amino-propionanilide 
• 64-17-5 ethanol 
• 1126-00-7 1-phenylpyrazole 
• 936-53-8 1-phenyl-4,5-dihydro-1H-pyrazole 
• 5003-71-4 3-bromopropylamine hydrochloride 

Downstream Products

• 187149-87-7 1-phenyl-1,4,5,6-tetrahydropyrimidine 
• 74360-07-9 3,4,5,6-tetrahydro-1-phenylpyrimidine-2(1H)-thione 
• 15037-08-8 {Ni(OC₆H₄CHN(CH₂)3NHC₆H₅)2} 
• 14282-04-3 {Ni(OC₆H₃(5-CH₃)CHN(CH₂)3NHC₆H₅)2} 

Relevant articles and documents

Insight into structural requirements for selective and/or dual CXCR3 and CXCR4 allosteric modulators

Based on the previously published pyrazolopyridine-based hit compound for which negative allosteric modulation of both CXCR3 and CXCR4 receptors was disclosed, we designed, synthesized and biologically evaluated a set of novel, not only negative, but also positive allosteric modulators with preserved pyrazolopyridine core. Compound 9e is a dual negative modulator, inhibiting G protein activity of both receptors. For CXCR4 receptor para-substituted aromatic group of compounds distinguishes between negative and positive modulation. Para-methoxy substitution leads to functional antagonism, while para-chloro triggers agonism. Additionally, we discovered that chemotaxis is not completely correlated with G protein pathways. This is the first work in which we have on a series of compounds successfully demonstrated that it is possible to produce selective as well as dual-acting modulators of chemokine receptors, which is very promising for future research in the field of discovery of selective or dual modulators of chemokine receptors.

Salts of 2- or 3-haloalkylamines in the synthesis of N-aminoalkyl derivatives of heterocyclic and aromatic amines

Reactions of 2-haloethyl- or 3-halopropylamine salts with NH-substrates (indoline, 1,2,3,4-tetrahydroquinoline, aniline, and N-ethylaniline) in the presence of NaHCO3 in water furnished various N-aminoalkyl derivatives of heterocyclic and aromatic amines.

An efficient and recyclable chitosan supported copper(II) heterogeneous catalyst for C-N cross coupling between aryl halides and aliphatic diamines

A useful and convenient methodology has been developed for synthesis of mono N-arylated aliphatic 1,2- and 1,3-diamines and amino alcohols. A highly efficient and renewable heterogeneous chitosan supported copper(II) catalyst has been employed for the C-N cross coupling between aryl halides and aliphatic diamines/amino alcohols. The main advantages of this reaction are the high yields of the products, reduced reaction time, convenient work up procedure, renewability of the catalyst, and less metal contamination of the products. All these factors make the present C-N cross coupling reaction economical, green, and sustainable.