474317-28-7

Basic information

• Product Name: (S)-2-(1-Hydroxy-1-methylethyl)pyrrolidine hydrochloride
• Synonyms: (S)-2-(1-Hydroxy-1-methylethyl)pyrrolidine hydrochloride;2-PyrrolidineMethanol, α,α-diMethyl-, hydrochloride (1:1), (2S)-
• CAS NO: 474317-28-7
• Molecular Formula: C₇H₁₅NO*ClH
• Molecular Weight: 0
• Mol File: 474317-28-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-2-(1-Hydroxy-1-methylethyl)pyrrolidine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(1-Hydroxy-1-methylethyl)pyrrolidine hydrochloride(474317-28-7)
• EPA Substance Registry System: (S)-2-(1-Hydroxy-1-methylethyl)pyrrolidine hydrochloride(474317-28-7)

Safety Data

• Hazardous Substances Data: 474317-28-7(Hazardous Substances Data)

Usage

Description

(S)-2-(1-Hydroxy-1-methylethyl)pyrrolidine hydrochloride is a chiral pyrrolidine derivative with a hydroxyl group and a methyl substituent, used as a chiral building block in the pharmaceutical industry for the synthesis of various pharmaceuticals and fine chemicals.

Uses

Used in Pharmaceutical Industry:
(S)-2-(1-Hydroxy-1-methylethyl)pyrrolidine hydrochloride is used as a key intermediate for the synthesis of drugs with biological activity, such as antipsychotic and antidepressant medications, due to its unique properties and versatility in organic synthesis.
Used in Agrochemical Production:
(S)-2-(1-Hydroxy-1-methylethyl)pyrrolidine hydrochloride is used as a chiral building block in the production of agrochemicals, contributing to the development of effective and targeted agricultural products.
Used in Specialty Chemicals Synthesis:
(S)-2-(1-Hydroxy-1-methylethyl)pyrrolidine hydrochloride is utilized in the synthesis of specialty chemicals, leveraging its unique structural features and reactivity for creating a variety of chemical compounds with specific applications.

Upstream product

• 147-85-3 L-proline 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 59936-29-7 (S)-N-(tert-butoxycarbonyl)proline methyl ester 

Downstream Products

• 51207-68-2 (2S)-N-Benzyloxycarbony-2-(1'-hydroxy-1'-methylethyl)pyrrolidine 
• 1357921-01-7 (E)-4-fluoro-N-(6-(((S)-2-(2-hydroxypropan-2-yl)pyrrolidin-1-yl)methyl)-1-((1s,4R)-4-(isopropylcarbamoyl)cyclohexyl)-1Hbenzo[d]imidazol-2(3H)-ylidene)benzamide 

Relevant articles and documents

New route for the synthesis of chiral hydrazine SADP

A convenient route for the synthesis of (S)-1-amino-2-(1-methoxy-1- methylethyl)pyrrolidine (SADP) was established. The route involved three key steps viz. the Grignard addition to the N-Boc-proline ester (1), nitrosation to the aminoalcohol hydrochloride (3) and O-methylation to the alcohol group of N-nitrosopyrrolidine (4). (S)-1,1-dimethyl-tetrahydropyrrolo[1,2-c]oxazol-3-one (6) was also obtained via the reaction of (S)-1-Boc-2-(1-hydroxy-1-methylethyl) pyrrolidine (2) with sodium hydride.

Novel chiral amine oxide ligand and preparation method thereof

The invention provides a novel chiral amine oxide ligand and a preparation method thereof. The method uses a simple amino acid or an amino acid derivative as a raw material, the raw material is modified, the modified material reacts with substances such as a coupling agent and an alkali, and therefore the pincher configuration chiral ligand compound is obtained, that is, the chiral amine oxide ligand. The chiral amine oxide ligand provided by the invention has a structure of a non-simple linear chain, has a soft skeleton in the molecular structure, contains a recognition gene containing heteroatoms such as oxygen or nitrogen, and can well coordinate with a series of metals and realize high enantioselectivity and high reactivity in a non-symmetric reaction; and the preparation method is simple, the steps are few, and the raw materials are cheap and easy to obtain.

NOVEL BETULINIC SUBSTITUTED AMIDE DERIVATIVES AS HIV INHIBITORS

The present invention relates to novel betulinic substituted amide compounds of formula (I); and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, X, Y, Z1, Z2, Z3 and are Formula (II) as defined herein. The invention novel betulinic substituted amide derivatives, related compounds, and pharmaceutical compositions useful for the therapeutic treatment of viral diseases and particularly HIV mediated diseases.