474352-69-7Relevant articles and documents
Solvent-free mechanochemical Buchwald-Hartwig amination of aryl chlorides without inert gas protection
Shao, Qiao-Ling,Jiang, Zhi-Jiang,Su, Wei-Ke
, p. 2277 - 2280 (2018)
A solvent-free Buchwald-Hartwig amination had been developed under high-speed ball-milling conditions, which afforded the desired products with moderate to high yields. The addition of sodium sulfate was found to be crucial for improving both the performance and the reproducibility. Comparative solvent-free stirring experiments implicated the importance of mechanical interaction for the transformation, and the inert gas was proved to be unnecessary for this amination.
Employing arynes in transition-metal-free monoarylation of aromatic tertiary amines
Bhojgude, Sachin Suresh,Kaicharla, Trinadh,Biju, Akkattu T.
supporting information, p. 5452 - 5455 (2013/11/19)
The highly monoselective N-arylation of aromatic tertiary amines using a transition-metal-free approach using arynes has been developed. The reaction afforded functionalized diaryl amines in moderate to excellent yield. High levels of functional group compatibility especially with halogen containing substrates, dyes and donor-acceptor systems, and high yields of products are the notable features of the present reaction.