47477-04-3

Basic information

• Product Name: (7S)-7-amino-1,2,3,9-tetramethoxy-6,7-dihydrobenzo[a]heptalen-10(5H)-one
• Synonyms: Benzo(a)heptalen-10(5H)-one, 7-amino-6,7-dihydro-1,2,3,9-tetramethoxy-, (S)-; Benzo[a]heptalen-10(5H)-one, 7-amino-6,7-dihydro-1,2,3,9-tetramethoxy-, (S)-
• CAS NO: 47477-04-3
• Molecular Formula: C₂₀H₂₃NO₅
• Molecular Weight: 357.4003
• Mol File: 47477-04-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 626.6°C at 760 mmHg
• Flash Point: 287°C
• Density: 1.25g/cm³
• Vapor Pressure: 1.29E-15mmHg at 25°C
• Refractive Index: 1.597
• CAS DataBase Reference: (7S)-7-amino-1,2,3,9-tetramethoxy-6,7-dihydrobenzo[a]heptalen-10(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (7S)-7-amino-1,2,3,9-tetramethoxy-6,7-dihydrobenzo[a]heptalen-10(5H)-one(47477-04-3)
• EPA Substance Registry System: (7S)-7-amino-1,2,3,9-tetramethoxy-6,7-dihydrobenzo[a]heptalen-10(5H)-one(47477-04-3)

Safety Data

• Hazardous Substances Data: 47477-04-3(Hazardous Substances Data)

Upstream product

• 186581-53-3 diazomethane 
• 3482-37-9 trimethylcolchicinic acid 
• 2730-81-6 (S)-7-Benzylidenamino-1,2,3,9-tetramethoxy-6,7-dihydro-5H-benzoheptalen-10-on 
• 102491-74-7 (+/-)-N-deacetylisocolchicine 
• 64-86-8 colchicine 
• 73307-44-5 7-amino-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one 
• 209810-38-8 N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl) acetamide 
• 102491-70-3 (+/-)-N-(trifluoroacetyl)deacetylcolchiceine 
• 102491-72-5 (+/-)-N-(trifluoroacetyl)deacetylisocolchicine 
• 477-27-0 colchiceine 
• 7469-68-3 (S)-7-((Ξ)-benzylidenamino)-10-hydroxy-1,2,3-trimethoxy-6,7-dihydro-5H-benzo[a]heptalen-9-one 

Relevant articles and documents

Semisyntheses, X-Ray Crystal Structures and Tubulin-Binding Properties of 7-Oxodeacetamidocolchicine and 7-Oxodeacetamidoisocolchicine

Commercially available (-)-colchicine (1) has been converted, via deacetylcolchiceine (4), into a mixture of 7-oxodeacetamidocolchicine (2) and 7-oxodeacetamidoisocolchicine (3).The X-ray structures and tubulin-binding properties of these title ketones are described.

13C and 1H-NMR assignments for colchicine derivatives

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