474922-82-2

Basic information

• Product Name: 1,2-dioleoyl-sn-glycero-3-phosphoethanolaMine-N-[Methoxy(polyethylene glycol)-350] (aMMoniuM salt)
• Synonyms: 1,2-dioleoyl-sn-glycero-3-phosphoethanolaMine-N-[Methoxy(polyethylene glycol)-350] (aMMoniuM salt);1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] ammonium salt;14:0 PEG 2000 PE;alpha-[(9R)-6-Hydroxy-6-oxido-1,12-dioxo-9-[(1-oxotetradecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphapentacos-1-yl]-omega-methoxypoly(oxy-1,2-ethanediyl) ammonium salt
• CAS NO: 474922-82-2
• Molecular Formula: (C2H4O)n.C35H68NO10P.NH3
• Mol File: 474922-82-2.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: 1,2-dioleoyl-sn-glycero-3-phosphoethanolaMine-N-[Methoxy(polyethylene glycol)-350] (aMMoniuM salt)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-dioleoyl-sn-glycero-3-phosphoethanolaMine-N-[Methoxy(polyethylene glycol)-350] (aMMoniuM salt)(474922-82-2)
• EPA Substance Registry System: 1,2-dioleoyl-sn-glycero-3-phosphoethanolaMine-N-[Methoxy(polyethylene glycol)-350] (aMMoniuM salt)(474922-82-2)

Safety Data

• Hazardous Substances Data: 474922-82-2(Hazardous Substances Data)

Usage

Description

1,2-dioleoyl-sn-glycero-3-phosphoethanolaMine-N-[Methoxy(polyethylene glycol)-350] (ammonium salt) is a PEG-modified phospholipid conjugate that plays a crucial role in the formation of sterically stabilized liposomes. These liposomes exhibit low reticuloendothelial system uptake and increased circulation duration, allowing for more effective targeting of cells.

Uses

Used in Pharmaceutical Industry:
1,2-dioleoyl-sn-glycero-3-phosphoethanolaMine-N-[Methoxy(polyethylene glycol)-350] (ammonium salt) is used as a lipid additive for studying its effect on the phase properties of hydrated monoolein. This helps in understanding the behavior of the compound in different environments and its potential applications in drug delivery systems.
Used in Biomedicine:
1,2-dioleoyl-sn-glycero-3-phosphoethanolaMine-N-[Methoxy(polyethylene glycol)-350] (ammonium salt) is used in the formation of liposomes encapsulating hemoglobin (LEHs). These liposomes can be beneficial in the development of oxygen-carrying blood substitutes and other medical applications.
Used in Targeted Drug Delivery:
1,2-dioleoyl-sn-glycero-3-phosphoethanolaMine-N-[Methoxy(polyethylene glycol)-350] (ammonium salt) is used as a stabilizing lipid in the preparation of folate receptor-targeting magneto liposomes. This allows for the development of targeted drug delivery systems that can specifically target cancer cells and other diseases.
Used in Nanotechnology:
1,2-dioleoyl-sn-glycero-3-phosphoethanolaMine-N-[Methoxy(polyethylene glycol)-350] (ammonium salt) might be used for graphene surface modification, enabling the study of protein translocation and other applications in the field of nanotechnology.
Used in Membrane Technology:
1,2-dioleoyl-sn-glycero-3-phosphoethanolaMine-N-[Methoxy(polyethylene glycol)-350] (ammonium salt) might be suitable for the preparation of floating bilayer lipid membranes. These membranes can be used in various applications, such as biosensors and artificial cell membranes.

Biochem/physiol Actions

The neutral hydrophilic polyethylene glycol (PEG) moiety in 14:0 favors efficient inhibition of protein adsorption during graphene nanopores modification.